Testing and Diagnostics Library
Every article, presentation, spotlight, and news item we've tagged to Testing and Diagnostics.
Showing 193–216 of 314
Reduction of glycation stress as a geroscience intervention: protocol for a pilot RCT in postmenopausal women
A pilot randomized controlled trial investigates whether reducing glycation stress—the accumulation of sugar-derived damage to proteins—can slow aging markers in postmenopausal women. Glycation is a hallmark of aging that accelerates decline across multiple physiological systems, making this intervention relevant to the practical toolkit of longevity medicine.
Death prediction app launches ‘AI health concierge’
Death Clock has launched Life Lab, an AI-driven health concierge that integrates blood biomarker analysis with personalized preventive guidance to help users close the gap between their current and optimized projected lifespan. The service aggregates laboratory testing, medical records, and wearable data to identify actionable interventions across four major chronic disease categories.
Reversing epigenetic aging in egg cells
Epigenetic changes—reversible modifications to DNA that alter gene expression without changing the genetic code—drive the aging of oocytes (egg cells), with implications for fertility preservation and age-related reproductive decline. Interventions targeting these epigenetic mechanisms show potential to restore oocyte function and extend reproductive healthspan.
Longevity and disease insights now in 20/20 BioLabs blood test
20/20 BioLabs launched OneTest for Longevity, a blood test combining inflammatory biomarkers, lifestyle data, and AI to identify chronic disease risk before clinical symptoms emerge. The platform translates biomarker patterns into actionable dietary and lifestyle modifications, addressing inflammation and stress response as primary drivers of aging and age-related disease.
Broad Epigenetic Shifts in the Aging Drosophila Retina Contribute to Its Altered Diurnal Rhythmic Transcriptome
Aging retinas undergo extensive epigenetic reprogramming affecting approximately 40% of rhythmically expressed genes, driven primarily by decreased histone H3K4 methylation rather than changes to core circadian clock factors. These chromatin-level shifts disrupt the diurnal transcriptional rhythms critical for retinal function and systemic circadian synchronization.
Social Connection Slows Aging Through Measurable Biology
Positive psychosocial exposures—joy, belonging, purpose, and social connection—function as biologically meaningful determinants of aging rates, operating through inflammatory, autonomic, and neuroendocrine pathways. The JoyScore Experiment quantifies these experiences using wearable neurotechnology and epigenetic markers, revealing preliminary evidence that active engagement in collective experiences correlates with slower biological aging trajectories.
Junyue Cao on How the Body Ages, Cell by Cell
Researchers using single-cell epigenomic profiling across seven million cells from 21 mouse tissues identified that approximately one-quarter of all cell types undergo significant shifts during aging, with many changes coordinated across organs and divergent between sexes. This comprehensive atlas reframes aging research from studying isolated signaling pathways to understanding organism-level cellular reorganization, establishing a foundation for therapies targeting aging mechanisms rather than individual diseases.
TMRW lands $7m to expand longevity clinics
TMRW, an Australian longevity platform, secured $7 million in seed funding to expand clinical services and deepen biological age assessment through epigenetic testing in partnership with TruDiagnostic. The company differentiates itself by analyzing approximately 1,700 biological data points and integrating clinical support alongside diagnostics, moving beyond dashboard-only models.
Can AI outsmart Alzheimer’s? $6.2m grant fund says yes
A $6.2 million NIH grant funds AI-driven analysis of 1,800 Alzheimer's-linked genes to identify genetic targets upstream of amyloid pathology, shifting focus from symptomatic treatment to early-stage vulnerability. Current amyloid-targeting drugs slow progression at best; identifying genetic determinants of susceptibility may enable earlier, more precise intervention before neurodegeneration becomes symptomatic.
Continuous Blood Pressure Monitoring Without Cuffs
Sky Labs received UK regulatory approval for CART PLATFORM, a cuffless ring-based blood pressure monitor that integrates wearable hardware, mobile app, and cloud analytics. The authorization enables prescription distribution through UK pharmacies and hospitals, establishing clinical-grade continuous blood pressure monitoring as an accessible diagnostic tool.
Telomere Restoration in Blood Cells Without Adverse Effects
Elixirgen is advancing two distinct therapeutic approaches for rare diseases: EXG-7001, a locally administered dystrophin mRNA for Duchenne muscular dystrophy, and EXG-34217, which uses engineered stem cells to achieve sustained telomere elongation in patients with telomere biology disorders. Early Phase 1/2 data demonstrates telomere lengthening without adverse events over 24 months, establishing proof of concept for a mutation-independent intervention in a class of diseases where cellular aging accelerates prematurely.
Continuous Blood Pressure Monitoring Shifts Cardiovascular Risk Assessment
Sky Labs' CART BP pro ring meets clinical standards for cuffless blood pressure monitoring and achieved regulatory clearance across major markets. The device demonstrates that wearable continuous monitoring can achieve accuracy equivalent to traditional methods, expanding clinical adoption pathways for non-invasive cardiovascular surveillance.
Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults
Higher diet quality correlates with slower epigenetic aging and reduced mortality risk in two large U.S. cohorts, with epigenetic age acceleration (GrimAgeEAA) explaining approximately 44% of the diet-mortality association in one cohort. The relationship is partially confounded by physical activity and integrated lifestyle factors, indicating that diet operates within a broader system of behavioral and biological aging pathways rather than in isolation.
Accelerated Aging Drives Early-Onset Cancer Across Generations
Younger generations show accelerated biological aging relative to their chronological age, a gap that correlates with rising early-onset cancer incidence. This widening generation-to-generation disparity suggests modern environmental exposures are driving cellular-level aging that manifests as cancer risk in individuals under 50.
A cellular atlas of aging comes into focus
A single-cell chromatin atlas across 21 tissues reveals that aging involves coordinated, sex-specific regulatory remodeling rather than random molecular decay. The coordinated shifts across anatomically distinct organs suggest systemic drivers—circulating signals, immune tone, endocrine cues—offering both mechanistic insight and practical constraints for intervention design.
AI predicts who will decline faster in Alzheimer’s
Machine learning models trained on routine clinic data predict individual rates of cognitive and functional decline in Alzheimer's disease and mild cognitive impairment with greater accuracy than population averages. Early identification of specific functional vulnerabilities—such as difficulty with finances or meal preparation—enables targeted interventions before independence is lost.
Short‐Term Dietary Intervention Alters Physiological Profiles Relevant to Ageing
A 4-week dietary intervention in adults aged 65–75 reduced KDM-derived biological age estimates, with the greatest effects seen in high-carbohydrate and semi-vegetarian groups. This rapid shift in composite biomarkers suggests diet produces measurable physiological changes relevant to aging trajectories, though longer-term data are needed to establish impact on disease risk.
Social isolation accelerates molecular aging via epigenetic pathways
Social experiences correlate with mortality risk through measurable physiological pathways: epigenetic aging, allostatic load, and health status. This evidence demonstrates that the quality and frequency of social engagement directly influence aging rate and disease burden at the molecular level.
A glycolytic metabolite puts the brakes on cGAS-driven aging
Phosphoenolpyruvate, a glycolytic metabolite, suppresses cGAS-driven inflammation through a direct molecular interaction. The age-related decline in PEP availability explains the transition from metabolic stability to chronic inflammation and neurodegeneration.
AI Maps Shared Disease Pathways to Target Aging
Gero secured $34 million in total equity funding to advance an AI platform that identifies drug targets across multiple age-related diseases by analyzing longitudinal medical records and molecular data. The company's physics-based approach to drug discovery represents a shift toward computational screening of shared pathways in aging rather than single-disease intervention.
HCCaging: a liver physiological aging-related biomarker for hepatocellular carcinoma diagnosis based on transcriptome data
Researchers identified HCCaging, a transcriptome-based biomarker that reflects liver aging patterns and improves hepatocellular carcinoma diagnosis. This tool bridges the gap between cellular aging processes and cancer risk stratification, offering earlier detection potential before advanced disease.
Skin as a window into systemic aging: NUS-L'Oréal study
L'Oréal and NUS Medicine are investigating whether skin aging correlates with systemic aging across multiple organ systems in the same participants. This within-person comparison approach could establish skin as a practical biomarker for biological aging, offering an accessible alternative to invasive measures like blood draws and imaging.
Human Longevity launches personal AI‑powered longevity app
Human Longevity has released an AI-powered mobile app that analyzes biometric, lifestyle, and genetic data to generate personalized health recommendations across nutrition, exercise, sleep, and preventive care. The platform's utility depends on the quality of data interpretation and user adherence to recommendations over time.
Roche gets CE mark for Alzheimer’s risk blood test
Roche has obtained CE mark approval for a blood test that identifies ApoE4 carriers, a genetic variant associated with increased Alzheimer's risk. This test streamlines risk stratification and treatment planning by enabling clinicians to prioritize patients for further evaluation and guide therapeutic decisions, particularly regarding amyloid-targeting therapies that carry differential risk profiles based on ApoE4 status.