Testing and Diagnostics Library
Every article, presentation, spotlight, and news item we've tagged to Testing and Diagnostics.
Showing 1–24 of 306
Whole-body MRI screening detects early cancers, aneurysms
EHE Health and Prenuvo have partnered to offer discounted whole-body MRI screening to select members, making radiation-free organ surveillance more accessible across 200+ U.S. clinics. The screening detects structural abnormalities, early-stage malignancies, and organ disease before symptom onset in under one hour.
Biological clocks age within a day without you aging!
Biological age clocks derived from DNA methylation patterns show significant day-to-day fluctuations within individuals, independent of actual chronological aging. This instability raises critical questions about their reliability for clinical application and longevity intervention assessment.
Sex-Specific Biological Age Test Quantifies Organ Aging and Treatment Response
Generation Lab released SystemAge 2.1, a biological age test measuring 460+ biomarkers across 21 organ systems with sex-specific analysis and 99% validated accuracy. The platform tracks organ-level aging trajectories and quantifies treatment response to interventions including stem cells and plasma exchange, enabling practitioners to detect accelerated aging earlier and monitor intervention efficacy with precision.
Epigenetic clocks measure drift, not aging itself
Epigenetic clocks quantify the cumulative drift in DNA methylation patterns that occurs with aging, yet their functional relationship to aging outcomes remains poorly defined. Understanding what these clocks actually measure—rather than assuming they capture aging itself—is essential for interpreting their clinical utility in longevity assessment.
Epigenetic aging signatures unlock precision intervention pathways
Epigenetic clocks measure aging at the molecular level by tracking DNA methylation patterns and gene expression changes. Decoding these signatures reveals specific biological pathways driving accelerated aging, enabling targeted interventions before functional decline becomes apparent.
IgG Glycans Reverse Aging Markers via Plasma Exchange
IgG glycan patterns—sugar structures attached to immune antibodies—function as modifiable biological aging markers that predict mortality risk and respond to interventions like therapeutic plasma exchange. Analysis of over 20,000 individuals across 42 studies establishes glycans as measurable indicators of immune aging that shift toward healthier profiles with targeted interventions.
Biological age tests reveal what slows or hastens aging – but they’re useful only for researchers, not consumers
Epigenetic aging clocks measure chemical changes to DNA to estimate biological age, but they are research tools designed for population-level study, not reliable for individual health assessment. Consumer products marketing these tests as personal health indicators misrepresent their validity and clinical utility.
Biological Noise Limits Epigenetic Clock Accuracy
Methylation-based epigenetic clocks demonstrate technical reliability but are vulnerable to short-term biological fluctuations that alter their outputs. This distinction between measurement consistency and biological stability has direct implications for using these clocks as aging biomarkers and intervention validators in clinical practice.
Your immune system now has a digital twin for longevity
A digital twin technology modeling immune system dynamics in real time enables predictive health outcomes rather than reactive assessment. This shift from static testing to continuous simulation represents a substantive advance in personalized longevity medicine.
GlycanAge to convene experts on inflammaging clinical applications
GlycanAge is hosting a conference with Mayo Clinic to advance clinical applications of glycan-based inflammaging markers, which can detect disease risk patterns up to a decade before symptomatic onset. The event aims to integrate chronic-inflammation testing into routine clinical practice.
When Doctors Prescribe Horoscopes: The Trouble With Biological Age Tests
Commercially available biological age tests based on epigenetic markers lack clinical validity, standardized accuracy measures, and actionable clinical utility. When physicians recommend them, they abandon evidence-based practice in favor of customer satisfaction, potentially replacing genuine health assessment with unfounded reassurance or unnecessary anxiety.
Gene Expression Aging Clock Simplifies Intervention Testing
Researchers have developed Pasta, a transcriptomic clock that measures age-related changes through gene expression patterns rather than DNA methylation. This tool addresses limitations in existing epigenetic clocks by offering a more accessible method to assess how interventions affect biological aging at the molecular level.
DEXA standardization essential for longevity tracking
DEXA body composition scanning has moved from clinical obscurity into mainstream longevity medicine, but rapid commercialization has created a quality control problem. Fitnescity Health's Clinical Integrity Standard addresses this by establishing voluntary benchmarks for testing environment stability, quality assurance, and clinical oversight—critical factors for reliable longitudinal tracking.
Blood protein clocks reveal true aging rate in populations
Blood protein signatures can now quantify biological aging with precision previously available only through complex genetic testing. Proteomic aging clocks measure the rate at which your body's protein landscape diverges from healthy baselines, offering a practical biomarker for assessing longevity risk and intervention responsiveness in large population studies.
IgG Glycan Age Predicts Mortality; Plasma Exchange Reverses It
IgG N-glycome patterns independently predict all-cause mortality across 20,405 individuals and respond to intervention, meeting established criteria for a valid aging biomarker. Therapeutic plasma exchange produced the largest reduction in glycan age at 0.4 years per month, positioning glycan structure as both a mechanistic link to chronic inflammation and a measurable target for lifespan extension.
The molecules you’ve been ignoring might be aging you
Glycans—sugar molecules attached to proteins and lipids—reflect cumulative biological stress and environmental exposure in ways that precede disease symptoms by years. Unlike fixed genetic risk, glycan patterns shift with inflammation, stress, and lifestyle, offering a measurable window into trajectories of aging before clinical disease emerges.
Klotho unveils AI-powered aging clock
Klotho Neurosciences has developed AI-powered genomics tests that measure biological age through DNA methylation and mRNA analysis of longevity-associated genes. This approach enables more precise stratification in clinical trials for neurodegenerative diseases, reducing confounding variables that arise when chronological and biological age diverge.
Longitudinal changes in epigenetic clocks predict long-term mortality
Longitudinal changes in epigenetic clocks—molecular markers of biological age—independently predict mortality over 24 years, independent of baseline biological age. This establishes that the rate of epigenetic change itself, not just absolute age status, carries clinically actionable information for longevity assessment.
Hone Health adds DEXA scans to personalized longevity platform
Hone Health integrated clinical-grade DEXA scans into its personalized longevity platform, enabling physicians to assess body composition changes—muscle, fat, and bone density—alongside metabolic and hormonal data. This shift from reactive screening to proactive monitoring allows earlier detection of metabolic drift and interventions before functional decline.
New GlycanAge conference pushes inflammaging into care
GlycanAge's landmark conference aims to translate 25 years of inflammaging research into clinical practice by demonstrating that glycan analysis can detect disease risk up to a decade before symptoms emerge. This shift from reactive to anticipatory medicine requires both clinical validation and a fundamental change in how patients and providers interpret asymptomatic risk signals.
Hone Health integrates BodySpec DEXA scans into longevity OS
Hone Health integrated BodySpec DEXA scanning into its longevity platform, enabling real-time body composition, bone density, and metabolic rate assessment within clinical care plans. This shift moves bone health screening from reactive post-65 assessment to proactive longitudinal tracking across younger populations.
Superpower partners with Grail to add Galleri cancer screening
Superpower has integrated Galleri, a multi-cancer early detection blood test, into its preventative health platform. Data from PATHFINDER 2 showed that adding Galleri to standard screening increased cancer detection more than seven-fold, with over half of detected cancers identified at stage I or II.
OMICmAge is a multiomic biological aging clock using electronic medical records
Researchers developed OMICmAge, a DNA-methylation-based biological aging clock integrating proteomic and metabolomic data from 31,000 electronic medical records. The measure predicts mortality and age-related disease risk with performance comparable to or superior to existing biomarkers, offering a scalable tool for quantifying biological aging status.
Life Time brings VO₂ max and metabolic testing to the masses
Life Time's nationwide rollout of SpiroFit metabolic testing brings laboratory-grade VO₂ max and fuel-utilization data into mainstream fitness clubs, enabling members to identify metabolic inflection points and train with precision rather than assumption. This democratization of metabolic testing shifts a central longevity marker—previously available only to elite athletes—into accessible measurement for the general population.