Testing and Diagnostics Library
Every article, presentation, spotlight, and news item we've tagged to Testing and Diagnostics.
Showing 169–192 of 314
Annovis partners with NeuroRPM on Parkinson’s study
Annovis is combining continuous movement monitoring via FDA-cleared AI with skin-based alpha-synuclein biomarkers to measure treatment response in a 36-month Parkinson's trial. This dual approach—capturing real-time motor dysfunction alongside objective pathological markers—establishes measurable endpoints for evaluating buntanetap's disease-modifying potential.
Life sciences analytics market to reach $23.17b by 2033
The global life sciences analytics market is projected to double from $11.1 billion in 2024 to $23.17 billion by 2033, driven by AI-enabled drug discovery, clinical trial optimization, and precision medicine workflows. This infrastructure expansion directly influences how treatments are identified, validated, and personalized to individual patients.
Insilico and Eli Lilly Announce a Major Collaboration
Eli Lilly's $2.75 billion collaboration with Insilico Medicine represents a shift from software licensing to pipeline asset acquisition, validating AI-driven drug discovery as a viable approach to therapeutic development. This partnership signals pharmaceutical industry confidence in computational approaches to identifying and developing novel compounds, with potential applications across multiple disease areas including aging-related conditions.
AI-built intrabodies target Alzheimer’s within
Researchers used AI to redesign antibody fragments that can function inside human cells, targeting misfolded proteins linked to Alzheimer's, Parkinson's, Huntington's, and motor neurone disease. This intracellular delivery approach addresses a fundamental limitation of conventional antibodies, which cannot access disease-driving proteins within neurons.
Breakthrough scan differentiates LATE from Alzheimer’s
PET and MRI imaging can now differentiate LATE (limbic-predominant age-related TDP-43 encephalopathy) from Alzheimer's disease in living patients, addressing a diagnostic gap that has resulted in widespread misclassification. Since LATE arises from different pathology (TDP-43 protein clumping) than Alzheimer's (amyloid and tau accumulation), accurate differentiation is essential for appropriate treatment selection and prognosis.
Biologically Younger Individuals, as Identified by MARK‐AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age
Biological age, calculated from a 10-marker panel, correlates with HDL cholesterol, vitamin D, and immune function (CD4+ ratio) independently of chronological age. Subjects with lower biological age scores showed favorable values in these markers, suggesting they function as drivers of the aging process rather than mere correlates.
Genetic and molecular factors underlying human longevity and epigenetic aging
Epigenetic aging—the divergence between chronological age and biological age—emerges as a measurable marker influenced by both genetic predisposition and modifiable molecular factors. Understanding these mechanisms provides actionable insight into why some individuals age more slowly at the cellular level and how interventions targeting epigenetic signatures may extend healthspan.
Imaging-derived biological age across multiple organs links to mortality and aging-related health outcomes
Imaging-derived biological age—a measure of structural aging across multiple organs—independently predicts mortality and age-related disease risk beyond chronological age. This multi-organ assessment reveals that heterogeneous aging patterns across tissues provide clinically actionable information for longevity planning and intervention timing.
EEG Software Maps Cognitive Processing Before Clinical Decline
VoxNeuro received FDA 510(k) clearance for software that analyzes brain electrical activity through standardized cognitive tasks, providing clinicians with quantified measures of neural function against a reference database of nearly 20,000 healthy adult data points. The tool supports assessment of cognitive processing without delivering diagnosis, positioning it as an objective biomarker for brain function relevant to early detection and monitoring.
Blocking telomere alarms restores blood production in aging
Blocking the DNA damage response at telomeres restores blood cell production and reduces senescence in aged mice, suggesting a pharmacological approach to counteract hematopoietic dysfunction driven by telomere shortening. This targets a fundamental mechanism of aging rather than its downstream effects.
Telomere Signaling Inhibition Restores Aging Immunity
Blocking telomeric DNA damage signaling through targeted inhibition of telomeric noncoding RNAs restores blood cell production and immune function in aged and telomerase-deficient mice, with comparable improvements observed in human hematopoietic stem cells. This finding identifies a specific molecular mechanism driving hematopoietic aging and suggests a therapeutic pathway for restoring immune competence in advanced age.
Stem Cell Turnover Drives Epigenetic Aging Across Species
A unified mathematical model of stem cell dynamics explains how DNA methylation patterns change with age across mammalian species, positioning stem cell turnover as a primary mechanism driving epigenetic aging. This work integrates diverse aging signatures into a coherent biological framework, shifting focus from methylation patterns themselves to the underlying cellular processes that generate them.
Physical Fitness Is Negatively Associated With DNA Methylation‐Based Risk of Aging‐Related Diseases
Physical fitness metrics correlate with DNA methylation patterns of circulating proteins, revealing molecular pathways that link muscular strength, aerobic capacity, body composition, and cognitive function to reduced risk of age-related diseases. This molecular mapping enables patient-level disease risk stratification based on combined fitness and epigenetic measurements.
Plasma Proteomic Profiling of Young and Older Adults Identifies Candidate Biomarkers of Biological Aging at the Intersection of Age and Disease
Proteomic analysis identified 311 plasma proteins whose expression patterns correlate with both chronological age and disease burden in older adults, representing candidate biomarkers of biological aging. These proteins suggest shared regulatory pathways between aging and chronic disease progression and may enable risk stratification and intervention monitoring.
Personalized Nutrition: Test Before Supplement
Personalized nutrition's value lies not in accumulating supplements but in identifying and correcting specific deficiencies through testing, then addressing root causes via dietary change. Overuse of untargeted supplementation creates nutrient imbalances that contradict health optimization goals.
AI-driven aging therapies target root biology over symptoms
AI-driven drug discovery is shifting medicine from treating downstream diseases to targeting aging biology itself, enabling personalized interventions tailored to individual biological signatures. This represents a fundamental reconceptualization of the therapeutic development process—from disease-specific pipelines to restoration of youthful cellular function.
Continuous Blood Pressure Monitoring Reveals Hidden Cardiovascular Patterns
Hilo Core, an FDA-cleared wearable system, generates 30-35 daily blood pressure readings via optical sensing and periodic cuff calibration, shifting cardiovascular monitoring from episodic clinical snapshots to continuous behavioral tracking. This approach addresses a fundamental gap in preventive medicine: most vascular risk accumulates undetected between infrequent clinical measurements.
How Inflammaging Is Linked to Epigenetic Aging
A Cell Genomics study demonstrates that age-related systemic inflammation (inflammaging) correlates with epigenetic aging as measured by established epigenetic clocks. This connection bridges two major aging hallmarks and suggests chronic low-grade immune activation reflects measurable changes in gene expression patterns independent of overt disease.
Continuous Blood Pressure Monitoring Replaces Cuff-Based Snapshots
Sky Labs' CART ring has received UK medical device authorization, representing a shift from intermittent cuff-based blood pressure monitoring to continuous, wearable cardiovascular tracking. Regulatory approval of cuffless rings signals that healthcare systems now recognize continuous biometric data collection as clinically legitimate, with implications for early detection and long-term cardiovascular risk management.
Continuous Hormonal Monitoring Reveals Gaps in Annual Testing
Continuous hormonal monitoring through wearable technology may address a fundamental gap in women's healthcare: the inadequacy of annual or biannual blood tests to capture hourly hormonal fluctuations. This shift from static snapshots to dynamic tracking could reveal patterns that isolated clinical measurements systematically miss, particularly during perimenopause and across reproductive transitions.
Home EEG Sleep Monitoring Achieves Clinical-Grade Accuracy
Integration of at-home EEG sleep monitoring into decentralized clinical trials enables objective measurement of sleep architecture with 88-96% agreement to laboratory polysomnography. This addresses a critical measurement gap in CNS studies where sleep quality directly influences neurological outcomes and therapeutic response.
Home sleep apnea testing now distinguishes obstructive from central events
Sunrise Air, an FDA-cleared at-home sleep test that monitors mandibular jaw movement alongside respiratory sensors, enables multi-night testing without disposable components. The device applies AI algorithms to distinguish obstructive from central apneas, addressing diagnostic complexity in a condition affecting over 900 million people globally.
Immune aging mechanisms revealed through bioengineered systems
Bioengineering tools—including biomaterial scaffolds, organoid systems, and tissue-targeted delivery mechanisms—enable direct interrogation of immune aging at the cellular and tissue level. These approaches bridge mechanistic understanding and therapeutic translation, offering specific pathways to modulate age-related immune dysfunction.
AI systems integration reshapes longevity beyond single biomarkers
Immorta Bio proposes that longevity optimization depends not on identifying a single aging biomarker, but on integrating thousands of biological signals through artificial intelligence, digital models, and patient-controlled data. This systems-based approach addresses a critical gap in precision medicine: the inability of isolated measurements to capture the body's interconnected complexity.