Testing and Diagnostics Library
Every article, presentation, spotlight, and news item we've tagged to Testing and Diagnostics.
Showing 265–288 of 314
Home Blood Sampling Unlocks Protein Analysis at Scale
Alamar Biosciences has developed a dried blood spot extraction kit enabling high-sensitivity protein analysis from fingerstick samples collected at home, potentially accelerating large-scale longevity research by reducing barriers to frequent, consistent biosampling across diverse populations.
Identification of distinct and shared biomarker panels in different manifestations of cerebral small-vessel disease through proteomic profiling
Proteomic analysis identifies distinct and overlapping protein signatures across different manifestations of cerebral small-vessel disease, revealing shared involvement of vascular, immune, and neuronal pathways. Plasma protein panels show predictive capacity for cerebrovascular events, establishing measurable biomarkers for disease stratification and risk assessment.
Similar minds age alike: an MRI similarity approach for predicting age-related cognitive decline
Brain structural similarity patterns on MRI predict individual rates of cognitive decline better than chronological age alone, suggesting that neural architecture itself encodes aging trajectories. This offers a measurable biological marker for identifying cognitive vulnerability before clinical decline becomes apparent.
Gait speed predictors shift across midlife and aging
Gait speed in middle and older adults correlates with specific physical and cognitive measures that vary across the age spectrum. Walking pace is a reliable marker of overall functional capacity and longevity risk, with certain predictors becoming more influential at different life stages.
Physics-based aging models shift geroscience from observation to prediction
Gero has secured $17 million in new funding to develop physics-based mathematical models of aging that move beyond observation toward prediction. The company's framework treats aging as a process governed by quantifiable physical laws rather than an accumulation of isolated cellular damage, positioning the field to transition from descriptive geroscience to predictive intervention.
Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction
Telomerase (TERT) in myeloid cells prevents senescence and pro-inflammatory polarization through mechanisms independent of telomere length. Loss of myeloid TERT drives foam cell formation, dyslipidemia, pulmonary fibrosis, and cardiac dysfunction—establishing TERT as essential for preventing aging-associated multi-organ pathology.
Immune Cell Aging Drives Atherosclerosis via Telomerase Loss
A correction to prior research clarifies the role of telomerase in myeloid cell function and atherosclerosis progression. The findings demonstrate that telomerase loss in immune cells accelerates dyslipidemia, foam cell accumulation, and downstream organ damage—connecting immune cell aging to systemic cardiovascular and pulmonary pathology.
Preventive Health Data Integration Catches Hidden Disease Risk
Everlab, an Australian healthtech platform, raised $42 million to consolidate fragmented health data and enable early disease detection before clinical symptoms emerge. The funding reflects growing investor recognition that preventive intervention—identifying risk factors years ahead of disease onset—may prove more cost-effective and clinically valuable than reactive treatment.
Aging enters the Parkinson’s lab
Preclinical Parkinson's research has relied on young animal models and acute toxin paradigms that fail to capture the disease's age-dependent biology. The PD-AGE roadmap calls for aging-integrated models—using genetic systems with gradual phenotypes and crossing them with accelerated aging strains—to better reflect how Parkinson's actually develops in older humans and improve translational reliability.
Nocturnal Function Reveals Hidden Cardiovascular Decline
Emagene.life and Adam Health have partnered to deliver AI-driven men's health optimization across Southeast Asia, integrating wearable biodata tracking with functional medicine assessment. The collaboration centers on detecting physiological decline through early biomarkers—particularly nocturnal erectile function as a cardiovascular and metabolic health indicator—before symptomatic disease emerges.
#391 ‒ Colorectal cancer screening: importance of early screening, colonoscopy as a screening and preventive tool, and how to build a personalized strategy
Colorectal cancer is uniquely interceptable through early screening before malignancy develops, making colonoscopy a critical preventive tool. Personalized screening strategies enable individuals to reduce cancer incidence and mortality through proactive detection and removal of precancerous lesions.
Immune Aging Clock Identifies COVID-19 Acceleration Effect
Immune repertoire sequencing reveals systematic remodeling of T and B cell populations with age, with a critical inflection point around 60 years characterized by reduced clonal diversity and expanded hyperspecific clones. COVID-19 infection accelerates these aging signatures, suggesting the virus triggers biological immune senescence comparable to years of natural aging.
Circulating levels of insulin-like growth factor binding protein 7 are associated with risks of chronic diseases and death
Circulating insulin-like growth factor binding protein 7 (IGFBP7) independently predicts risk of chronic disease and mortality across multiple conditions, suggesting it functions as a systemic biomarker of aging and physiological decline. Measurement of IGFBP7 may offer clinicians a quantifiable indicator of disease susceptibility that extends beyond traditional risk factors.
The Timing of Meals Matters for Biological Aging
Meal timing significantly influences biological aging rates, with earlier first meals (before 8 a.m.) and last meals between 3 p.m. and 7 p.m. associated with slower aging in heart, liver, and whole-body measures. The relationship is nonlinear and depends on age, sex, caloric intake, and organ-specific responses.
Liver Protein Signatures Outpredict Mortality Risk in Aging
Circulating protein signatures enriched in liver and immune markers predict all-cause mortality in older adults with superior performance to conventional clinical risk factors. A 20-protein score achieved C-index 0.81 for mortality discrimination and validated consistently across independent cohorts, establishing plasma proteomics as a scalable biomarker platform for biological age stratification.
Behavioral Medicine Beats Medication in Chronic Disease Reversal
Nourish, an AI-assisted nutrition clinic, secured $100 million in Series C funding to scale a model treating chronic disease through behavior change and dietitian-led care rather than medication alone. The company addresses a critical gap in healthcare: chronic conditions develop through years of metabolic drift, yet most interventions remain reactive rather than preventive, with behavioral sustainability determining long-term outcomes.
Dog Gene Therapy Shows Early Safety in Aging Trial
Genflow Biosciences reports early safety and survival benefits in its SLAB gene therapy trial in 24 aging beagles, with no adverse events observed at three months. The study represents an emerging model in longevity research: using companion animals as a translational bridge between laboratory studies and human trials, where faster aging enables observation of long-term changes within years rather than decades.
Blood Biomarkers Close Alzheimer's Diagnostic Gap in Latin America
C2N Diagnostics and SouthGenetics are expanding blood-based biomarker testing for Alzheimer's detection across Latin America and the Caribbean, addressing a critical gap between diagnostic innovation and accessibility in underserved regions. This partnership prioritizes implementation over technology alone, recognizing that earlier identification of Alzheimer's pathology becomes actionable only when systems can deploy it at scale.
The case for space as a model of accelerated aging
Spaceflight stressors including microgravity and radiation accelerate biological aging pathways in astronauts, providing a compressed model for studying age-related disease mechanisms. This natural experiment offers direct evidence of how extreme environmental conditions trigger aging processes that occur more gradually in terrestrial populations.
AGGF1 Decline Drives Age-Related Hypertension Through Mitochondrial Dysfunction
AGGF1, an endothelial protein that declines with age, regulates blood pressure through a signaling pathway that controls mitochondrial function and nitric oxide production. Loss of AGGF1 accelerates vascular aging and elevates blood pressure in male mice, while restoring AGGF1 expression reverses these changes, identifying a potential intervention target for age-related hypertension.
Multifaceted Declines in Everyday Decision-Making in Older Adults: A Think-Aloud Study
Older adults exhibit measurable declines in everyday decision-making driven by sensory and cognitive changes, with environmental design and support structures demonstrating capacity to mitigate these effects. This directly impacts functional independence and quality of life across the lifespan.
Single-cell analysis of the human immune system reveals sex-specific dynamics of immunosenescence
Single-cell immune profiling across nearly 1,000 adults reveals sex-specific patterns of immune aging, with females demonstrating more extensive age-related remodeling of immune function. These findings establish a biological basis for observed sex differences in inflammatory disease prevalence and infection susceptibility across the lifespan.
FDA rewrites drug approval rules and longevity stands to gain
The FDA has shifted its drug approval standard from requiring two pivotal clinical trials to accepting one, citing advances in biological understanding, biomarker validation, and trial design sophistication. This regulatory change has direct implications for aging-related therapeutics, where slow biological processes and prevention-focused interventions have historically faced approval barriers under the two-trial requirement.
Single CRISPR Treatment Targets Inherited Heart Disease at Genetic Root
Scribe Therapeutics secured $25 million in funding to advance two CRISPR-based gene therapies targeting inherited cardiovascular disease—specifically lipoprotein(a) and triglyceride metabolism—toward human clinical trials. This represents a meaningful shift in cardiovascular medicine from lifelong management of risk factors toward one-time genetic intervention at the source of inherited disease.