Testing and Diagnostics Library
Every article, presentation, spotlight, and news item we've tagged to Testing and Diagnostics.
Showing 241–264 of 314
Are levels of DHEAS indicative of subjective health – results of the population-based longitudinal CARLA study
Dehydroepiandrosterone sulfate (DHEAS) levels correlate with subjective health perception in a longitudinal population study, suggesting this adrenal steroid may serve as a physiological marker for how individuals experience their own health status. The finding bridges objective biochemistry with subjective well-being, relevant to understanding which biomarkers meaningfully predict health experience across the lifespan.
Electrocardiogram derived heart age models agreement, accuracy and predictive ability in the Tromsø study
Electrocardiogram-derived heart age models show moderate agreement with chronological age but demonstrate significant individual variation, with predictive accuracy for cardiovascular outcomes varying substantially depending on the specific model used. This suggests ECG-based age estimates require careful interpretation and cannot yet replace traditional risk assessment tools.
Fasting-Mimicking Diet Reverses Metabolic Disease Through Cellular Repair
Fasting-mimicking diets trigger autophagy and cellular regeneration through a precise five-day protocol, with clinical evidence demonstrating reversal of insulin resistance and reduced medication dependency in metabolic disease. The mechanism operates as a repair system distinct from emergency symptom management—the body's inherent capacity to reorganize damaged tissue during the refeeding phase.
Biological sex shapes divergent trajectories of immune aging
Single-cell profiling of nearly 1,000 individuals demonstrates that immune aging follows distinct cellular and transcriptional trajectories between sexes, with female participants showing more pronounced cellular and molecular remodeling than males. This finding reveals that sex-based differences in immune function are not uniform across aging and must inform how we assess and support immune resilience across the lifespan.
The Timing of Meals Matters for Biological Aging
Meal timing correlates with biological aging rates across multiple organs, with optimal outcomes occurring when the first meal is consumed before 8 a.m. and the last meal between 3 p.m. and 7 p.m., while extended feeding windows and late first meals accelerate aging markers in the heart and liver. This relationship varies substantially by age, sex, and metabolic health status, suggesting meal timing functions as a modifiable variable in aging trajectories.
BioAge reports positive Phase 1 data for BGE-102
BGE-102, an oral NLRP3 inhibitor, demonstrated rapid and substantial reductions in high-sensitivity C-reactive protein (85–86% median reduction) and inflammatory markers in a Phase 1 trial, with 87–93% of treated participants normalizing hsCRP levels and no serious adverse events reported. This early evidence suggests a therapeutic approach to systemic inflammation that may have relevance to age-related disease prevention.
Aging dictates tumor-specific genomic alterations across cancer types
Aging systematically reshapes the genomic landscape of tumors across cancer types, with age-dependent mutations and chromosomal alterations that diverge from patterns seen in younger patients. This finding reframes cancer as partly an age-driven disease of accumulated cellular errors, with direct implications for prevention, detection, and treatment stratification based on age-related biology.
Age‐Like Methylation Changes of HSCs in GADD45B Knockout Mice Define Methylation Sites Associated With Loss of Function
GADD45B deletion induces DNA methylation patterns resembling age-associated changes in hematopoietic stem cells, yet these methylation alterations occur without functional decline. The research distinguishes between methylation signatures and actual loss of HSC capacity, providing a resource to identify which methylation sites causally drive age-related hematopoietic dysfunction.
Association Between Vitamins and Slower Biological Aging
A large epidemiological analysis of 15,050 participants found that higher intake of vitamins, particularly C and B2, correlates with slower biological aging as measured by multiple aging biomarkers. The association remained significant after adjustment for socioeconomic and lifestyle factors, suggesting a direct relationship between vitamin adequacy and the rate of biological aging.
Blood Biomarkers Replicate Alzheimer's Brain Imaging Data
DiamiR Biosciences is collaborating with AlzLabs to validate blood-based biomarkers for Alzheimer's disease, measuring phosphorylated tau-217, amyloid ratios, and neurofilament light alongside proprietary microRNA signatures. This work addresses a critical diagnostic gap: replacing expensive, inaccessible PET imaging with accessible blood testing that captures the neurobiological complexity of early-stage disease.
Aerobic Capacity Encodes Distinct Brain Methylation
Rats with naturally high aerobic capacity exhibit distinct DNA methylation patterns in the hippocampus and elevated signaling through MAPK, AKT-mTOR, and synaptic pathways in cortical tissue—a molecular signature present independent of exercise training. This suggests intrinsic aerobic capacity creates a measurable biochemical state in aged brain tissue that may support cognitive resilience.
Mitigating the Hawthorne effect in aging research
Observation-induced behavioral changes in aging research can produce biomarker shifts equal to or larger than the interventions being tested. This Hawthorne effect is particularly pronounced in geroscience trials and must be methodologically distinguished from genuine biological aging modulation.
Blood biomarkers detect cognitive decline before symptoms
DiamiR Biosciences will present three posters at the 2026 Alzheimer's Association International Conference focused on blood-based biomarkers for cognitive decline detection, including plasma APOE genotyping and circulating microRNA signatures. These biomarkers represent a shift toward non-invasive, early-stage identification of neurodegeneration risk before clinical symptoms manifest.
Modifying Role of Sustainable Diets on the Association Between Particulate Matter and Biological Aging: The Guangzhou Biobank Cohort Study
Higher PM 2.5 and PM 10 exposure accelerates biological aging markers in older adults, but adherence to plant-based dietary patterns significantly attenuates this acceleration. The protective effect is strongest in individuals with genetic predisposition to shorter lifespan.
Abu Dhabi opens a real-world test lab for longevity
Abu Dhabi is establishing an integrated health infrastructure that combines clinical records, genetic data, and continuous wearable monitoring into a real-time evidence system designed to shift healthcare from reactive treatment to predictive intervention. This represents a systematic approach to testing longevity interventions within functioning health systems rather than isolated research environments.
MicroRNA profiles in plasma-derived extracellular vesicles across the human lifespan
Plasma extracellular vesicles carrying microRNAs show age-specific expression patterns that correlate with biological aging across the human lifespan. These circulating biomarkers may serve as measurable indicators of systemic aging processes and inform stratification of longevity risk.
Biomarkers of oxidative damage as a tool to investigate frailty syndrome in older women
Oxidative damage biomarkers correlate with frailty in older women, providing measurable indicators of cellular stress that precede functional decline. Identifying these markers enables earlier intervention before frailty manifests clinically.
Cilia Suppression Reverses Gum Senescence via AKT Activation
Primary cilia accumulation in aged gingival tissue drives fibroblast senescence and periodontal inflammation. Suppressing ciliogenesis reverses this process through AKT signaling activation, offering a mechanistic target for managing age-related gum disease and tissue deterioration.
Fallopian tube cancer market growth driven by targeted therapies
This article reports on pharmaceutical market expansion in fallopian tube cancer treatment through targeted therapies and companion diagnostics, driven by improved genetic testing for BRCA1/BRCA2 mutations and earlier detection. The development of biomarker-driven, personalized approaches addresses a rare gynecologic malignancy where prevention and early intervention now have clinical pathways.
Liver Regeneration Shifts From Theory to Tissue Reconstruction
Regenerative medicine is advancing from theoretical to practical application in liver repair, with organoid technology and engineered tissues now enabling researchers to reconstruct damaged liver tissue and potentially restore function. This represents a fundamental shift from managing liver decline to actively rebuilding organ structure—a capability with significant implications for extending healthspan in aging populations.
IFN-γ emerges as a simple blood clue to Alzheimer’s
Interferon-gamma (IFN-γ), a common immune signaling molecule, emerges as a blood-based biomarker capable of distinguishing Alzheimer's disease from healthy aging with high accuracy, particularly in individuals carrying the APOE ε4 genetic variant. The finding suggests a scalable pathway for early detection and monitoring, shifting the disease profile toward immune-driven pathology.
Cell Type‐Specific Expression of p16, p21, and p53 Reveals Age‐Dependent Glial Senescence in the AppNL‐G‐F Mouse Model of Alzheimer's Disease
Microglial and astrocytic cells in an Alzheimer's disease mouse model exhibit progressive senescence linked to amyloid pathology, while neurons remain unaffected. This cell-type-specific senescence signature identifies glial cells as primary targets for senescence-directed therapeutic intervention in Alzheimer's disease.
C2N Diagnostics partners with Codex Genetics to expand Alzheimer’s testing in Hong Kong
C2N Diagnostics and Codex Genetics are expanding access to PrecivityAD2, a blood test measuring amyloid biomarkers to assess Alzheimer's risk in asymptomatic or early-symptomatic individuals. Early detection via non-invasive biomarker assessment enables intervention before cognitive decline becomes clinically apparent, shifting Alzheimer's management from reactive to preventive.
Gordian Bio unveils scalable in‑vivo screening platform preprint
Gordian Bio describes a scalable in-vivo mosaic screening platform that uses barcoded CRISPR libraries and single-cell readouts to establish causal gene-disease relationships in living organisms. This approach accelerates therapeutic target discovery by testing multiple genetic perturbations simultaneously, reducing experimental variation and improving efficiency compared to traditional methods.