Testing and Diagnostics Library
Every article, presentation, spotlight, and news item we've tagged to Testing and Diagnostics.
Showing 217–240 of 314
Gamma imaging reveals precise GI transit patterns
Researchers developed samarium-153 oxide-loaded polystyrene particles as radiotracers for measuring gastrointestinal transit time using gamma scintigraphy. This imaging approach enables direct visualization of food and material movement through the entire digestive tract, providing quantitative data on transit kinetics that conventional methods cannot capture.
The retina-body axis: proteomic mechanisms linking oculomics and clinical traits in a female aging cohort
Retinal protein signatures correlate with systemic aging markers and clinical traits in women, establishing the eye as a window into whole-body physiological age. These oculometric measures may enable earlier detection of aging-related dysfunction across multiple organ systems.
Sex Differences in Associations Between Adversity and Biological Ageing
Childhood adversity associates with accelerated biological aging markers primarily in women, while adulthood adversity shows stronger associations with aging markers in men. This sex-specific pattern suggests distinct windows of physiological vulnerability across the lifespan that warrant consideration in aging research and clinical intervention timing.
Laser-induced epigenetic reversal restores skin age markers
A non-ablative fractional laser treatment produced measurable shifts in skin epigenetic markers associated with aging, with 83.9% of age-related CpG sites showing DNA methylation changes consistent with biological reversal. Visible improvements in pigmentation and texture paralleled molecular changes over a six-month period, suggesting the intervention operates at both the genetic regulation and tissue-level domains.
Glycosylation Dysregulation Drives Alzheimer's Neurodegeneration
Hyperglycosylation—excessive attachment of complex carbohydrates to proteins—emerges as a hallmark molecular feature of Alzheimer's disease, concentrated in memory and cognitive regions. Experimental reduction of glycosylation improved behavioral outcomes in animal models, suggesting this metabolic alteration may be a causal driver rather than merely a downstream consequence.
Multimodal data analysis reveals asynchronous aging dynamics across female reproductive organs
Deep learning analysis of histological and transcriptomic data from over 300 female donors reveals that reproductive organs age asynchronously rather than in lockstep, with menopause functioning as a critical inflection point detectable in circulating protein signatures. This challenges the assumption of synchronized aging across organ systems and identifies tissue-specific vulnerability windows relevant to longevity and disease prevention.
Clair Health launches wearable hormone intelligence
Clair Health has launched a non-invasive wearable that uses multimodal biosensors and AI to infer continuous hormonal patterns across the female lifespan, moving beyond episodic blood tests and calendar-based tracking. The device collects skin temperature, heart rate variability, sleep, and breathing data as proxies for endocrine state, positioning hormonal monitoring as a prevention tool rather than a fertility marker.
Association of brain age gap with BMD and incident fractures in the UK Biobank
Accelerated brain aging—measured as the difference between chronological age and brain imaging markers—correlates with lower bone mineral density and increased fracture risk independent of chronological age. This suggests neurobiological aging patterns may predict skeletal fragility and fracture vulnerability in midlife and older adults.
Telomir Pharmaceuticals reports new data on epigenetic modulation mechanism
Telomir-1 (Telomir-Zn) modulates intracellular metal balance by increasing zinc and reducing iron, influencing epigenetic regulation and cellular stability without triggering cytotoxic stress. This mechanism addresses oxidative stress and genomic integrity pathways implicated in aging and cancer biology.
Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age
Microglia—the brain's resident immune cells—exhibit distinct transcriptional patterns and morphological changes with age, with subcellular mRNA localization directly influencing their functional capacity. This work establishes how aging alters the molecular foundation of neuroinflammation, a process central to cognitive decline and neurodegenerative disease progression.
Mitochondrial Function Drives Bimodal Breast Aging Patterns
Breast tissue ages along distinct patterns controlled by mitochondrial function, with some individuals experiencing episodic windows of vulnerability at ages 45 and 65 rather than gradual decline. This bimodal aging signature aligns with the observed peaks in human breast cancer incidence and suggests tissue-level aging trajectories may explain age-related disease distribution.
Agentis, Ultrahuman tie wearables to Longevity Quotient
Agentis Longevity and Ultrahuman have integrated continuous glucose monitoring and wearable biomarker data into a clinical scoring system (Longevity Quotient) designed to bridge the gap between real-time metabolic data and actionable preventive care. The partnership addresses low engagement in preventive health practices by making personalized, data-driven interventions accessible at scale.
Nuclear Enlargement Marks Muscle Aging at Cellular Level
Deep learning analysis of skeletal muscle histology identifies nuclear enlargement and altered nuclear density as quantifiable markers of aging, with high diagnostic accuracy (86.2%). These morphometric changes correlate with transcriptional programs governing chromatin remodeling, proteostasis, and mitochondrial function, establishing a scalable biomarker framework validated across inflammatory myopathies and suggesting potential clinical application as a muscle aging clock.
From wrist data to lifespan: elucidating inflammation-driven biological aging via activity rhythms captured by wearable devices
Wearable devices tracking activity rhythms reveal that irregular movement patterns correlate with systemic inflammation and accelerated biological aging. This connection between circadian disruption and aging rate offers a quantifiable marker for longevity risk that precedes clinical disease.
The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging
Phosphoenolpyruvate, a glycolytic metabolite, suppresses cGAS-STING-driven inflammation and improves cognitive function in Alzheimer's disease models while correlating with healthy aging markers in humans. This identifies a metabolic checkpoint that regulates innate immune signaling during aging.
New functional brain assessment system rolls out in the US
QuantalX Neuroscience has launched Delphi MD, an FDA-cleared non-invasive system that quantifies real-time functional brain network activity using transcranial magnetic stimulation, electroencephalography, and AI analytics. This technology enables clinicians to detect subtle changes in brain function before structural damage or cognitive decline becomes apparent, shifting neurological care from reactive symptom management to preventive assessment.
Estimating Vascular Age to Evaluate the Association Between Aging and Cardiovascular Disease
Vascular age acceleration, measured through a quantitative model, independently predicts cardiovascular disease risk beyond chronological age, with a 21–25% increased risk in those showing accelerated vascular aging. This metric enables earlier identification of individuals requiring intervention before overt disease manifestation.
AI-Designed Peptides Target Oral Delivery Breakthrough
LG AI Research and D&D Pharmatech are partnering to use artificial intelligence to design peptide therapeutics, compressing the molecular discovery timeline by generating novel candidates based on pattern recognition rather than manual search. This collaboration addresses both the design challenge and the delivery barrier that has limited peptide drug development, positioning AI as an active research participant rather than a background tool.
Unified Cardiometabolic Monitoring Closes Fragmented Diabetes Care Gap
Diathrive and AliveCor's partnership integrates diabetes and cardiovascular monitoring into a single platform, addressing the clinical reality that these conditions are physiologically linked yet typically managed in isolation. This integration targets employers seeking to reduce cardiometabolic risk through coordinated early detection rather than reactive disease management.
AI-Designed Oral Peptides Transform Drug Delivery Science
LG AI Research and D&D Pharmatech are collaborating to use artificial intelligence for designing oral peptide therapeutics, combining AI-driven molecular discovery with proprietary formulation technology to improve bioavailability and reduce development timelines. This partnership addresses a critical gap in drug delivery: the difficulty of administering peptides orally, which could expand treatment options for diseases currently managed only through injection.
Alzheimer's Therapies Shift Detection From Clinic to Home
Effective disease-modifying therapies for Alzheimer's disease are forcing a diagnostic infrastructure shift from academic research to scalable clinical detection. Early identification now determines treatment efficacy, requiring systems that can identify pathology years before cognitive symptoms emerge.
Twenty years on, cognitive training shows dementia signal
A 20-year follow-up of the ACTIVE trial found that speed-of-processing training with booster sessions reduced dementia diagnoses in older adults, a rare signal of efficacy in prevention research anchored to clinical diagnoses rather than cognitive test scores alone.
Mimio Health trial shows fasting‑mimetic delivers benefits without dieting
Mimio Health's fasting-mimetic therapy produced biomarker changes consistent with fasting physiology—including improved metabolic markers and enhanced fat metabolism—without dietary modification. The intervention was well tolerated and represents a pharmacological approach to accessing metabolic benefits traditionally associated with caloric restriction.
Updating risk models with real-world data
Longevity AI and Meir Medical Center are updating classical cardiovascular and metabolic disease risk models using contemporary real-world clinical data to improve early detection accuracy. This approach prioritizes practical prevention of the diseases causing the largest population-level health loss, rather than pursuing experimental aging interventions.