Men's Health Library
Every article, presentation, spotlight, and news item we've tagged to Men's Health.
Showing 1–18 of 18
Prostate cancer: a PSA on PSA
Prostate-specific antigen (PSA) screening remains an underutilized tool for early prostate cancer detection despite proven capacity to identify disease at more treatable stages. The clinical evidence supports selective screening in men at appropriate risk, yet implementation barriers persist in clinical practice.
From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late‐Onset Hypogonadism by Targeting Leydig Cell Senescence
Melatonin restores testosterone production in aging Leydig cells by addressing oxidative stress and mitochondrial dysfunction, offering a mechanism-based alternative to passive testosterone supplementation. This shift from symptom management to cellular repair has implications for age-related hormonal decline in men.
Global stagnation and misaligned priorities in BPH drug development: a 25-year landscape analysis of clinical trial registries
Benign prostatic hyperplasia drug development has stagnated over 25 years, with clinical trial pipelines showing minimal innovation and priorities misaligned with patient burden. This stagnation reflects a broader market failure in addressing age-related conditions that affect quality of life and functional independence in aging populations.
#388 — Prostate cancer screening: why current PSA guidelines are failing men and how modern tools improve early detection and save lives
Current PSA-based prostate cancer screening protocols miss clinically significant cancers and fail to distinguish aggressive from indolent disease, reducing detection effectiveness. Modern biomarkers and imaging technologies enable earlier identification of aggressive tumors when intervention is most effective, fundamentally altering outcomes for men at risk.
Ultra-processed foods impair sperm quality independent of weight
A controlled feeding study in young men demonstrates that ultra-processed food consumption impairs sperm quality and reproductive hormone profiles within weeks, independent of weight gain. This finding clarifies a direct mechanistic pathway between food quality and male fertility—a critical but underexplored link in longevity-focused clinical practice.
Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone
Middle-aged and older men with low testosterone demonstrate reduced mitochondrial respiration and decreased SIRT3 expression in vascular endothelial cells, indicating accelerated vascular aging through impaired oxidative stress regulation. This mechanism links testosterone deficiency directly to cardiovascular disease risk through mitochondrial dysfunction.
Nocturnal Function Reveals Hidden Cardiovascular Decline
Emagene.life and Adam Health have partnered to deliver AI-driven men's health optimization across Southeast Asia, integrating wearable biodata tracking with functional medicine assessment. The collaboration centers on detecting physiological decline through early biomarkers—particularly nocturnal erectile function as a cardiovascular and metabolic health indicator—before symptomatic disease emerges.
Loss of Chromosome Y Associates With Altered Immune Cell Trajectories and X‐Inactivation Features
Loss of chromosome Y in male leukocytes, detected in nearly 9% of cells in older men, produces cell-type-specific immune dysfunction characterized by altered monocyte differentiation and aberrant X-chromosome inactivation patterns. These molecular changes associate with increased risk for cardiovascular disease and cancer, suggesting LOY represents a meaningful driver of age-related immune decline in men rather than a neutral age-related marker.
Menopause as Prevention: Why Midlife Transitions Define Aging
Winona, a telehealth menopause platform, launched a branded supplement line designed to address sleep disruption, digestive issues, bone and muscle decline, and nutritional gaps during perimenopause and menopause. The move reflects a clinical shift from symptom management alone toward supporting the physiological foundations that determine long-term health outcomes in women.
Catalyst Precision Health debuts at-home men’s longevity care
Catalyst Precision Health launches an integrated model combining in-home testing, physician house calls, and continuous personalized care for men's longevity, addressing fragmentation in the current market where health data remains scattered across disconnected providers and platforms.
Stop treating women as an exception in aging science
Aging science built primarily on male biology has systematically misunderstood female physiology, leading to ineffective or harmful optimization strategies for women. A female-centered approach recognizes that women's hormonal cycles are rhythmic rather than erratic, and that sex-based differences in metabolism, hormone production, and social bonding represent distinct biological advantages requiring tailored intervention.
NAD+ Elevation Shifts Estrogen Balance in Menopausal Women
A seven-day pilot study of 40 women found that Basis supplementation correlated with self-reported reductions of 50% or more in hot flashes, bloating, and sleep disruption, alongside a statistically significant shift in estradiol-to-estrone ratio favoring estradiol dominance. The mechanism appears linked to NAD+ metabolism and estrogen balance during the menopausal transition.
Topical hair loss treatment restores coverage in women
Veradermics' topical VDPHL01 demonstrated measurable hair regrowth in women with androgenetic alopecia, producing mean increases of 22–23 hairs/cm² at six months and improvement in hair coverage in nearly 90% of participants, with no serious safety signals. These Phase 2 findings support advancement toward confirmatory trials and represent a potential treatment option for female pattern hair loss, where therapeutic options remain limited.
Menopause Symptom Clustering Accelerates Biological Aging
Women experiencing menopause report an average of nine concurrent symptoms, with 75% battling six or more simultaneously. This symptom clustering—particularly the co-occurrence of energy loss, weight gain, fatigue, and cognitive dysfunction—reflects systemic hormonal dysregulation rather than isolated complaints, with a median delay of one year before women access appropriate care.
Erectile dysfunction drugs and longevity
PDE5 inhibitors, established drugs for erectile dysfunction, are attracting early interest in longevity medicine for their capacity to improve vascular function and tissue resilience through nitric oxide signaling—not by targeting root causes of aging, but by supporting system performance under the stress of accumulated damage.
HPV Self-Testing Expands Cervical Cancer Prevention Access
Self-collected HPV testing at home offers a practical alternative to clinical Pap smears, potentially improving screening adherence by removing barriers to access and reducing friction in cervical cancer prevention. This shift from provider-administered to patient-directed screening represents a meaningful change in how early detection can reach broader populations.
Acorn Biolabs treats first patients in randomized hair regeneration trial
Acorn Biolabs has initiated a randomized, controlled trial of YOU, an autologous secretome derived from hair follicle stem cells, to treat androgenic alopecia. The study will measure changes in hair density, thickness, and patient outcomes against placebo, establishing whether personalized regenerative approaches offer clinically meaningful advantages over existing pharmacologic treatments.
Sex differences in aging demand mechanistic study, not statistical adjustment
Women outlive men globally yet experience higher rates of disability and age-related disease in those extra years—a disparity rooted in biological sex differences, reproductive aging trajectories, and menopause's systemic effects. GeroSCORE, a new $7.5 million NIH-funded center at USC, is designed to move beyond documenting these differences toward identifying the mechanistic underpinnings that could reveal intervention points applicable across populations.