Nature AgingMar 3, 2026
Estropausal gut microbiota transplant improves measures of ovarian function in adult mice
Transplanting gut microbiota from aging female mice into young adults restored ovarian hormone profiles, follicle development, and fertility markers, establishing a causal relationship between age-related changes in the microbiome and ovarian function decline. This demonstrates that microbiota composition directly regulates reproductive capacity independent of chronological age.