Therapies and Protocols Library
Every article, presentation, spotlight, and news item we've tagged to Therapies and Protocols.
Showing 25–48 of 79
Brain health ‘collaboratory’ focuses on non-invasive Alzheimer’s therapy
Cognito Therapeutics and Ochsner Health are partnering to test Spectris, a non-invasive neuromodulation device that delivers synchronized light and sound stimulation to restore gamma oscillations disrupted in Alzheimer's disease. Early evidence shows the approach slows cognitive decline and reduces brain volume loss, with the collaboration designed to evaluate real-world clinical implementation across diverse healthcare settings.
Inbrain completes enrollment in first human graphene brain study
Inbrain Neuroelectronics completed enrollment of a first-in-human trial implanting graphene cortical interfaces in eight patients undergoing neurosurgical tumor resection, demonstrating favorable safety and high-resolution neural signal capture without device-related adverse events. This represents early validation of graphene-based brain-computer interfaces for clinical applications.
LanCL1 protein restores cellular repair in neuropathic pain
Lanthionine Synthetase C-Like Protein 1 (LanCL1) has been identified as a therapeutic target for neuropathic pain, with LAT8881 and related Stressed Cell Protectant peptides demonstrating safety and clinically meaningful pain reduction in Phase 1b trials. This mechanism suggests a pathway to address chronic pain through cellular protection and repair rather than traditional analgesic approaches.
Radiofrequency nerve ablation reduces chronic back pain without opioids
The Intracept Procedure is a minimally invasive, radiofrequency-based ablation targeting the basivertebral nerve for chronic low back pain that has not responded to conservative care. Clinical evidence supports durable pain reduction and decreased opioid dependence in appropriately selected patients with specific MRI findings.
NeuroTherapia completes Phase 2a trial of NTRX-07 in Alzheimer’s
NeuroTherapia completed a Phase 2a trial of NTRX-07 in 48 Alzheimer's patients, demonstrating safety and tolerability with no serious adverse events in the treatment group. Exploratory endpoints showed encouraging trends toward cognitive stabilization and favorable biomarkers of neuroinflammation, warranting further investigation in larger trials.
NAD+ IV Therapy Supports Cellular Energy and DNA Repair
Aeon Clinic in Dubai offers intravenous NAD+ supplementation and micronutrient delivery, claiming support for metabolic function, DNA repair, and cognitive clarity through direct bloodstream administration. The clinical model emphasizes physician oversight and personalized protocols as distinguishing factors in the premium wellness space.
Niagen Bioscience secures patent for NR injections
Niagen Bioscience secured a US patent protecting intravenous and injectable formulations of nicotinamide riboside (NR), a NAD+ precursor molecule that declines with age and cellular stress. The patent extends protection through 2044 and positions the company to dominate clinical delivery of NAD+ boosters, a market rapidly expanding across wellness clinics.
Springfield Wellness Center marks 25 years of NAD+ IV therapy
Springfield Wellness Center has operated for 25 years using intravenous NAD+ therapy as part of a multimodal protocol for addiction recovery and brain restoration. The clinic's longevity and expansion suggest sustained clinical utility, though the evidence base and mechanistic clarity for NAD+ infusions in longevity contexts remain limited.
NAD+ IV Therapies Shift to Personalized Longevity Medicine
AEON Clinic in Dubai offers physician-supervised IV nutrient therapies and NAD+ treatments as part of a broader shift toward personalized health optimization focused on healthspan rather than lifespan. The clinic positions these interventions within longer-term health strategies rather than as standalone wellness experiences, reflecting emerging sophistication in how longevity medicine is being integrated into clinical practice.
Restore taps into consumer NAD+ interest
NAD+ awareness has transitioned from niche biohacker circles to mainstream consumer interest, with companies like Restore positioning supplementation as a long-term cellular maintenance strategy rather than a rapid intervention. The shift reflects a maturing longevity market moving away from anti-aging hype toward evidence-informed consistency.
A Combination NAD+ Treatment Has Benefits for Mice
Researchers demonstrated that combining NMN supplementation with apigenin—which inhibits NAD+ breakdown—restores muscle function and bone structure in aged mice. This dual approach addresses both supply and preservation of NAD+, a critical coenzyme in cellular energy metabolism and stress resistance.
A Combination NAD+ Treatment Has Benefits for Mice
Researchers demonstrated that combining NAD+ precursor supplementation (NMN) with apigenin, a compound that reduces NAD+ degradation, restores muscle function and bone structure in aged mice. This dual-mechanism approach addresses both NAD+ availability and preservation, with relevance to human aging given prior clinical evidence for NAD+ precursors in metabolic and respiratory function.
NAD+ Restoration Targets Muscle Aging at Molecular Level
A peer-reviewed analysis of nicotinamide riboside (NR) supplementation found that 1,000 mg daily for five months was associated with approximately 2.5 years of reduction in muscle epigenetic age acceleration, measured across multiple biological clocks. The findings suggest NAD+ restoration may influence molecular aging pathways in skeletal muscle beyond simple energy production, though researchers emphasize additional work is needed to establish causation.
Additional Cover
NAD+ preservation through dual mechanisms—inhibiting its depletion and enhancing its synthesis—delays cellular senescence while promoting musculoskeletal regeneration. This addresses a central constraint in aging: the body's declining capacity to maintain energy production and tissue repair as NAD+ levels fall with time.
Double‐Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal Regeneration
A combination of NMN and apigenin preserves NAD+ levels, activating SIRT3 to suppress cellular senescence and promote differentiation of muscle, bone, and cartilage precursor cells. The regimen also modulates the gut microbiota to increase production of phytosphingosine, an anti-aging metabolite, resulting in improved musculoskeletal function and exercise capacity in aged animals.
Beacon Biosignals is turning sleep into brain diagnostics
Beacon Biosignals has developed a home-based EEG headband that records brain electrical activity during sleep, enabling continuous longitudinal monitoring of neural patterns. This approach shifts brain health assessment from single-point diagnostic snapshots to scalable, repeatable data collection that can detect pathological changes years before symptom onset.
Smart earbuds bring EEG sleep modulation to consumers
NextSense has commercialized in-ear EEG earbuds that move beyond sleep tracking to real-time neural modulation, using closed-loop audio stimulation timed to reinforce slow-wave sleep. This represents a shift from passive measurement to active intervention in a domain central to longevity—though validation across heterogeneous populations and safety protocols remain open questions.
Supporting energy through menopause with NMN
NAD⁺ decline during menopause impairs mitochondrial function and energy production across multiple systems simultaneously. NMN, as a direct NAD⁺ precursor, bypasses rate-limiting steps in NAD⁺ biosynthesis to support cellular energy restoration and repair capacity.
Muscle epigenetic age reduction with NR supplementation
A pooled analysis of clinical trials and laboratory work found that five months of nicotinamide riboside supplementation correlated with approximately 2.5 years of reduction in muscle epigenetic age, measured by multiple clock algorithms. The finding suggests NAD+ precursor supplementation may influence age-related molecular signatures in skeletal muscle, though the company acknowledges results are preliminary and largely correlational.
Metabolic Aging: From Clinical Management to Systems Optimization
Metabolic health is transitioning from a narrow clinical category to a multidisciplinary optimization target, driven by consumer-oriented virtual care, continuous monitoring technologies, and integrated behavioral support. This shift recognizes metabolic function as a primary determinant of biological aging and systemic health, not merely weight management.
NADMED backs Cleveland Clinic transplant study
Cleveland Clinic's awarded research uses redox biology—specifically NAD and NADH measurement—to assess metabolic viability of donor organs during the ischemic period before transplantation. This work translates longevity science concepts into actionable clinical tools for organ quality assessment and transplant outcomes.
EEG AI models standardize sleep biomarkers across devices
Beacon Biosignals demonstrated AI-driven sleep staging and arousal detection algorithms alongside clinical validation data for its Waveband device in hypersomnia disorders. The platform's capacity to extract standardized digital biomarkers from multi-device EEG data positions it as a tool for both clinical assessment and pharmaceutical trial endpoints.
MDLifespan and Cenegenics expand toxin-clearing therapy
MDLifespan and Cenegenics are expanding access to Therapeutic Plasma Exchange (TPE), a procedure that removes environmental toxins, microplastics, and heavy metals from circulation to reduce chronic inflammation. The partnership positions toxin clearance as a foundational longevity strategy, addressing inflammation that undermines cognitive, metabolic, and cardiovascular function.
GNC adds MitoQ Pure and MitoQ NAD to The Drop
GNC has introduced MitoQ Pure and MitoQ NAD+ Dual Action supplements targeting mitochondrial function and oxidative stress reduction. Both formulations address energy production and cellular aging through distinct mechanisms—direct antioxidant support and NAD+ level optimization.