Regenerative Therapies Library
Every article, presentation, spotlight, and news item we've tagged to Regenerative Therapies.
Showing 145–168 of 297
Scarlet raises $4m as lab-grown blood matches donor cell survival
Scarlet Therapeutics has demonstrated that laboratory-grown red blood cells survive in circulation as long as donor-derived cells, validating a platform for scalable cell manufacturing and therapeutic delivery. This represents a critical proof-of-concept for replacing donor-dependent blood supply with engineered cells capable of both oxygen transport and targeted therapeutic function.
Urinary detection of therapy-induced senescence and fibrosis using an injectable albumin-based nanoprobe
Researchers developed an injectable nanoprobe that detects cellular senescence through urine analysis, using MMP-7 enzyme activity as a measurable marker. This enables non-invasive, real-time monitoring of treatment response in lung cancer and pulmonary disease, establishing a quantifiable method to track senescence burden during therapy.
Intracellular cholesterol removal opens cardiovascular repair pathway
Repair Biotechnologies has secured FDA Rare Disease Evidence Principles (RDEP) eligibility for REP-0003, an mRNA therapy targeting intracellular free cholesterol accumulation in homozygous familial hypercholesterolemia. This regulatory milestone enables a more tractable clinical pathway for a therapy designed to remove established atherosclerotic damage rather than simply manage lipid levels—a distinction with implications extending beyond inherited cholesterol disorders to broader cardiovascular aging.
Cellular retinoic acid-binding protein 1, CRABP1, in thyroid gland aging
Cellular retinoic acid-binding protein 1 (CRABP1) regulates thyroid aging through vitamin A metabolism and retinoic acid signaling. Dysfunction in this protein correlates with thyroid senescence, positioning CRABP1 as a potential biomarker and intervention target for age-related thyroid decline.
Perivascular Fat Control Restores Vessel Relaxation
A BET inhibitor (RVX-208) that suppresses stress-response gene transcription in perivascular fat restores blood vessel relaxation and reduces inflammatory markers in patients with obesity and hypertension. This approach targets the signaling interface between fat and vessel tissue rather than individual inflammatory molecules, demonstrating that perivascular adipose tissue dysfunction is a primary driver of endothelial impairment in cardiometabolic disease.
Clene reports full year 2025 results with ALS drug progress
Clene Inc. advanced CNM‑Au8, an investigational therapy targeting mitochondrial dysfunction in neurodegenerative diseases, with biomarker data showing statistically significant reductions in neurodegeneration markers linked to improved survival. The company narrowed its net loss to $26.2 million in 2025 and secured over $28 million in funding to support regulatory filings through 2027.
Vasa Therapeutics targets 2026 clinical entry for peripheral artery disease therapy
Vasa Therapeutics is advancing VS-214, an apelin peptide analog designed to promote new blood vessel formation and improve blood flow in peripheral artery disease patients, toward first-in-human trials in 2026. PAD affects 10–12 million Americans and causes approximately 400 non-traumatic amputations daily, representing a significant clinical need for pharmacological intervention.
Coultreon raises $125m for immune resilience
Coultreon Biopharma raised $125 million to advance COL-5671, an oral SIK3 inhibitor designed to restore immune balance rather than blunt inflammatory suppression in autoimmune disease. The approach targets a mechanism relevant to chronic immune dysregulation associated with aging, positioning the therapy as a potential bridge between disease treatment and healthspan optimization.
Mayo Clinic and Sana partner to advance Type 1 diabetes cell therapy
Mayo Clinic and Sana Biotechnology are collaborating to develop SC451, a hypoimmune-modified pancreatic islet cell therapy designed to restore glucose control in type 1 diabetes without requiring ongoing insulin or immunosuppression. The partnership establishes protocols for clinical delivery, patient selection, and monitoring to support Phase 1 trials beginning this year.
Restore Hyper Wellness kicks off NAD Month to educate on IV, IM therapies
Restore Hyper Wellness is promoting NAD supplementation through IV and intramuscular delivery formats, capitalizing on significant year-over-year increases in consumer search interest for NAD-related therapies. The initiative positions NAD precursors and direct NAD administration as tools for cellular energy optimization, though clinical evidence supporting broad longevity claims remains limited.
NAD+ webinar set to examine delivery dilemma
NAD+ delivery methods—pills, injections, and pens—are receiving increased clinical scrutiny as the molecule transitions from niche longevity therapy to mainstream wellness category. The effectiveness of NAD+ depends less on the molecule itself than on bioavailability, formulation quality, and whether patients maintain consistent use.
Senescent cells drive aging inflammation
Cellular senescence—the accumulation of non-dividing cells that secrete inflammatory factors—drives age-related decline in multiple organ systems. Understanding how senescent cells compromise tissue function and identifying interventions that clear or manage their activity offers a direct path to extending both healthspan and lifespan.
Niagen launches telehealth NAD+ injection platform
Niagen Bioscience launched a prescription-only telehealth platform delivering subcutaneous NAD+ injections at home, shifting nicotinamide riboside from over-the-counter supplement to clinician-directed pharmaceutical intervention. The model combines telehealth access with clinical oversight and compounded pharmaceutical-grade dosing, though the clinical evidence supporting NAD+ supplementation for meaningful longevity outcomes remains incomplete.
Niagen Bioscience secures patent for NR injections
Niagen Bioscience secured a US patent protecting intravenous and injectable formulations of nicotinamide riboside (NR), a NAD+ precursor molecule that declines with age and cellular stress. The patent extends protection through 2044 and positions the company to dominate clinical delivery of NAD+ boosters, a market rapidly expanding across wellness clinics.
Increasing Senolytic Effectiveness by Stressing Mitochondria
Mitochondrial stress emerges as a critical mechanism underlying senolytic effectiveness against senescent cells. This finding suggests that the therapeutic benefit of senolytics depends partly on their capacity to induce cellular energy stress, offering a framework for optimizing drug selection and combination strategies in senescence-targeted interventions.
Klotho unveils AI-powered aging clock
Klotho Neurosciences has developed AI-powered genomics tests that measure biological age through DNA methylation and mRNA analysis of longevity-associated genes. This approach enables more precise stratification in clinical trials for neurodegenerative diseases, reducing confounding variables that arise when chronological and biological age diverge.
Senolytic Treatment With Fisetin Reverses Age‐Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12
Fisetin, a plant-derived senolytic, reverses age-related endothelial dysfunction in aging mice by eliminating senescent endothelial cells and reducing the SASP factor CXCL12, which drives vascular dysfunction through oxidative stress and impaired nitric oxide production. This identifies a mechanistic pathway linking cellular senescence to cardiovascular aging and demonstrates functional recovery through targeted senolytic intervention.
Senescent Cells Block Cellular Cleanup in Aging
Cellular senescence and autophagy dysfunction accumulate with age, driving multiple organ system decline. Understanding how senescent cells disrupt normal repair mechanisms reveals intervention points for extending healthspan independent of chronological age.
Blocking telomere alarms restores blood production in aging
Blocking the DNA damage response at telomeres restores blood cell production and reduces senescence in aged mice, suggesting a pharmacological approach to counteract hematopoietic dysfunction driven by telomere shortening. This targets a fundamental mechanism of aging rather than its downstream effects.
Niagen Bioscience launches Niagen Plus telehealth platform
Niagen Bioscience launched Niagen Plus, a telehealth platform delivering prescription-only nicotinamide riboside (Niagen) via at-home subcutaneous injection. The injectable route is positioned to bypass first-pass hepatic metabolism and improve tissue bioavailability compared to oral administration.
Fisetin Reverses Chemotherapy-Induced Vascular Aging
Fisetin, a naturally occurring senolytic compound, reversed vascular dysfunction and aortic stiffening induced by doxorubicin in mice by suppressing senescent cells and their inflammatory secretions, restoring nitric oxide availability. This demonstrates a pharmacological pathway to counter drug-induced premature vascular aging.
Advancing senescence translation through the Senotherapeutics Biomarker Consortium
The Senotherapeutics Biomarker Consortium establishes standardized biomarkers for identifying and measuring cellular senescence across tissues and populations, enabling translation of senolytic therapies from research to clinical practice. This addresses a critical gap in longevity medicine: the ability to reliably detect senescent cells and track treatment response in living humans.
Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza
Senolytic treatment with ABT-263 reduced lung and intestinal inflammation and prevented long-term pulmonary damage in aged mice infected with influenza, though it did not reduce viral replication itself. The findings indicate that pre-existing senescent cells drive inflammatory pathology rather than viral control, suggesting a therapeutic target for improving outcomes in older adults.
DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment
Senolytic treatments did not reverse epigenetic signatures associated with cellular senescence, despite reducing senescent cell burden. This finding questions whether DNA methylation changes adequately capture senescence biology and whether current aging biomarkers respond as expected to geroscience interventions.