Regenerative Therapies Library

Every article, presentation, spotlight, and news item we've tagged to Regenerative Therapies.

All Library Articles Presentations Spotlights News

Showing 25–48 of 155

LifeSpan.ioFeb 27, 2026

Cellular Reprogramming: The Expert Roundup

Cellular reprogramming—the process of resetting aged cells to younger functional states through partial application of reprogramming factors—represents a fundamental shift in how aging is understood: not as irreversible damage accumulation, but as a modifiable biological state. Clinical trials are imminent, and the field has moved from theoretical elegance to therapeutic platform with potential applications across age-associated diseases.

Nature AgingFeb 3, 2026

Precision targeting of the SASP in cancer therapy

TGFβ signaling emerges as the primary tumor-promoting mechanism within senescent cells induced by platinum chemotherapy in ovarian and lung cancers. Targeting this pathway selectively could preserve the therapeutic benefit of chemotherapy while blocking its pro-tumor effects, addressing a critical vulnerability in current cancer treatment.

LifeSpan.ioMar 30, 2026

How a Growth Factor and SIRT1 Might Combat Disc Degeneration

FGF21, a growth factor that declines with age, delays intervertebral disc degeneration by upregulating SIRT1 and restoring mitochondrial quality control through the PINK1-Parkin mitophagy pathway. This mechanism addresses a primary driver of age-related lower back pain by counteracting cellular senescence in disc tissue.

LT WireFeb 20, 2026

Immortal Dragons backs 3D biofabrication to tackle organ failure

Immortal Dragons is directing capital toward 3D biofabrication technologies that use living cells and biocompatible materials to engineer functional tissues and vascular structures. This represents a strategic shift in longevity investment toward regenerative approaches that intervene before organ failure becomes clinically symptomatic.

Wiley Aging CellFeb 8, 2026

Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells From Old Individuals Towards Senescent Fibroblasts

Natural killer cells from older adults fail to clear senescent fibroblasts due to overactivation of the Cdc42 protein, which disrupts the cellular machinery required for releasing cytotoxic granules and producing ATP. Pharmacological inhibition of Cdc42 restores this clearing capacity and offers a potential therapeutic target for age-related disease driven by senescent cell accumulation.

Longevity.TechnologyFeb 6, 2026

Telomir Pharmaceuticals reports new data on epigenetic modulation mechanism

Telomir-1 (Telomir-Zn) modulates intracellular metal balance by increasing zinc and reducing iron, influencing epigenetic regulation and cellular stability without triggering cytotoxic stress. This mechanism addresses oxidative stress and genomic integrity pathways implicated in aging and cancer biology.

Longevity.TechnologyFeb 17, 2026

The shift from stem cells to signals

Clinical evidence shows transplanted stem cells often fail to survive beyond days, yet patients continue improving—suggesting the therapeutic mechanism resides in transient molecular signals rather than cell persistence. This shift from cellular replacement to signal-based regenerative therapy reframes aging as a coordination failure rather than a structural deficit, with profound implications for scalable longevity medicine.

Longevity.TechnologyFeb 2, 2026

PranaX lands $17m to harness exosomes in regenerative biologics

PranaX secured $17 million in Series A funding to develop exosome-based therapeutics licensed from UT MD Anderson, targeting age-related inflammation and tissue degeneration. The company plans to commercialize stem cell-derived exosome products for wellness applications and potentially clinical programs addressing chronic age-related conditions.

Wiley Aging CellFeb 2, 2026

Periodic Therapeutic Phlebotomy Mitigates Systemic Aging Phenotypes by Promoting Bone Marrow Function

Periodic therapeutic phlebotomy restores bone marrow function in aging models, reducing senescence markers and improving tissue integrity across multiple organ systems. The mechanism involves rebalancing hematopoietic homeostasis through rescue of mesenchymal and endothelial stem cells, suggesting a practical intervention with clinical translation potential.

Wiley Aging CellFeb 12, 2026

Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health

Young muscle-derived stem cells secrete pro-angiogenic and immunomodulatory proteins that decline with age. Systemic transplantation of these young cells into aged mice restored neuromuscular structure and function through paracrine signaling, with effects sustained for two months.

Wiley Aging CellApr 30, 2026

Plasma Dilution After Myocardial Ischemia–Reperfusion Injury Promotes Cardiac Repair, Heart Performance, and Recovery of Motor Function and Endurance in Old Mice

Plasma dilution performed 24 hours after myocardial ischemia–reperfusion injury in aged mice significantly improved cardiac function, reduced fibrosis and inflammation, and restored physical performance through enhanced cellular repair and modified inflammatory signaling pathways. This finding addresses a critical gap in aging-relevant cardiac research by demonstrating that manipulating the blood's humoral environment after acute injury can shift the trajectory of tissue recovery in older organisms.

Longevity.TechnologyMar 26, 2026

Pulmatrix and Eos merge to advance gerotherapeutics

Pulmatrix and Eos SENOLYTIX are merging to develop PTC-2105, a candidate designed to modulate mitochondrial function and clear senescent cells in sarcopenia and metabolic disease. The transaction signals a fundamental shift in biopharma toward targeting aging biology directly rather than its downstream manifestations.

Wiley Aging CellFeb 21, 2026

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice

FGF21 enhances lactate uptake and utilization in the aging brain, protecting against neuroinflammation-driven cognitive decline. This mechanism reveals how metabolic efficiency at the cellular level directly influences neuronal resilience during aging.

Wiley Aging CellApr 17, 2026

Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction

Telomerase (TERT) in myeloid cells prevents senescence and pro-inflammatory polarization through mechanisms independent of telomere length. Loss of myeloid TERT drives foam cell formation, dyslipidemia, pulmonary fibrosis, and cardiac dysfunction—establishing TERT as essential for preventing aging-associated multi-organ pathology.

Wiley Aging CellApr 3, 2026

Featured Cover

Plasma proteomic analysis of Swiss centenarians identifies a distinct protein signature associated with preserved youthfulness and longevity. This proteomic fingerprint offers a measurable biomarker set for aging trajectories and potential intervention targets.

Longevity.TechnologyMar 27, 2026

Rubedo reports early clinical signal for senotherapeutic drug

Phase 1 data for RLS-1496, a GPX4 modulator, demonstrate safety and dose-dependent target engagement alongside reductions in senescence markers and clinical improvement in inflammatory skin conditions. The drug operates through a dual mechanism: clearing senescent cells via ferroptosis while restoring redox balance in stressed neighboring cells, representing a shift toward cellular recalibration rather than indiscriminate senescent cell clearance.

Wiley Aging CellMar 20, 2026

FGF21‐Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

FGF21 activates a cellular repair pathway in spinal disc cells by upregulating SIRT1, which deacetylates FOXO3 and triggers mitochondrial autophagy, thereby suppressing cell senescence and slowing intervertebral disc degeneration. This identifies a targetable molecular axis with direct relevance to preventing age-related spinal structural decline and associated disability.

LifeSpan.ioMar 2, 2026

Rejuvenation Roundup February 2026

A February 2026 research roundup covering advances in cellular reprogramming, senolytic effectiveness, immune cell restoration, and cognitive interventions demonstrates multiple convergent pathways for addressing age-related decline. The collective findings suggest that aging is modifiable across multiple biological domains, with implications for clinical translation in vision, neurological, and metabolic disease.

Nature - npj AgingFeb 14, 2026

MicroRNA profiles in plasma-derived extracellular vesicles across the human lifespan

Plasma extracellular vesicles carrying microRNAs show age-specific expression patterns that correlate with biological aging across the human lifespan. These circulating biomarkers may serve as measurable indicators of systemic aging processes and inform stratification of longevity risk.

Longevity.TechnologyMar 27, 2026

Cellbricks Therapeutics secures €10 million to advance tissue implants

Cellbricks Therapeutics secured €10 million to advance biofabricated tissue implants toward clinical use, focusing initially on adipose tissue for soft tissue defects and wound healing. The funding supports preclinical validation and manufacturing scale-up for vascularized tissue alternatives to synthetic reconstructive implants.

Longevity.TechnologyMar 23, 2026

Garm adds Klotho to cell and gene therapy platform in Roatan

Garm LLC expanded its non-permanent plasmid gene therapy platform to include Klotho alongside existing follistatin and VEGF therapies, targeting mitochondrial function, inflammation reduction, oxidative stress management, and metabolic aging. The platform operates in Roatan, Honduras, positioning itself as a personalized longevity intervention without permanent genetic modification.

Longevity.TechnologyApr 22, 2026

Cells that heal? New Parkinson’s trial sparks hope

A Phase II clinical trial of XS411, a stem cell therapy designed to replace dopamine-producing neurons lost in Parkinson's disease, has advanced based on encouraging Phase I results showing improved motor function and no adverse events. The approach represents a shift from symptomatic management toward cellular repair, potentially restoring function rather than merely masking decline.

LifeSpan.ioFeb 6, 2026

First Human Cellular Reprogramming Trial Cleared by the FDA

Life Biosciences has received FDA clearance to begin the first human trial of cellular reprogramming, testing ER-100 against age-related vision diseases. This represents the first clinical translation of partial reprogramming technology, moving a three-decade research program from laboratory validation into human application.

Wiley Aging CellApr 2, 2026

In Vitro Modeling of Age‐Associated Lipid Mediator's Impact on Vascular Biology Following Platelet Concentrate Transfusion

Lipid mediators in platelet transfusions—particularly lysophosphatidic acid, lysophosphatidylcholine, and sphingosine-1-phosphate—decline with donor age and correlate with adverse transfusion reactions through altered platelet and endothelial cell activation. This finding suggests that donor age-related changes in lipid signaling directly influence transfusion safety and vascular biology.

Biological EDGE

Biohacking Starts With NO