Movement and Training Library
Every article, presentation, spotlight, and news item we've tagged to Movement and Training.
Showing 49–72 of 80
UNC45B Reduction With Aging: A Myofiber‐Intrinsic Promoting Factor for Sarcopenia
UNC45B, a myosin chaperone protein, declines with age and is required to maintain fast-twitch muscle force and mass. Loss of UNC45B in skeletal muscle triggers a cascade of systemic effects: reduced contractile capacity precedes atrophy, followed by bone fragility, lower body temperature, and sleep disruption.
Stem cell therapy might improve aging frailty
Stem cell therapy demonstrates potential to address frailty in aging by restoring cellular repair capacity and tissue regeneration. This approach targets a fundamental mechanism of aging decline rather than managing symptoms.
Why Complex Organisms Resist Aging Interventions
A theoretical framework explains why interventions that dramatically extend lifespan in simple organisms produce modest gains in mammals: biological complexity creates redundancy, tissue-specific effects, and compensatory feedback that limit the impact of single-pathway manipulation. This fundamental constraint shapes realistic expectations for longevity interventions across species.
[Articles] Repeated measures of physical activity before dementia diagnosis in community-dwelling older adults: a longitudinal study
Repeated measures of physical activity in community-dwelling older adults reveal that the protective association with dementia risk varies depending on timing relative to diagnosis, suggesting that activity patterns in the years immediately preceding cognitive decline may be more predictive than earlier lifetime activity. This finding reframes physical activity from a static risk factor into a dynamic variable whose relevance to dementia prevention depends on proximity to disease onset.
The brain doesn’t have to decline
Cognitive decline is increasingly recognized as preventable and reversible through targeted cognitive training and integrated lifestyle interventions, rather than an inevitable consequence of aging. A landmark 20-year study found that speed-processing training reduced dementia incidence by 25%, while clinical cases demonstrate substantial cognitive recovery when multiple physiological and psychological factors are addressed simultaneously.
Diosgenin Restores Muscle Stem Cell Function in Aging
Diosgenin, a plant-derived compound, activates SIRT1/PGC-1α signaling to restore satellite cell function and muscle mass in aged mice, demonstrating a mechanistic pathway relevant to age-related sarcopenia. The compound increased grip strength, exercise endurance, and muscle fiber size while upregulating myogenic markers and growth factors essential for muscle regeneration.
Why the wellness industry needs a new operating system
The wellness industry operates on infrastructure designed for episodic experiences rather than sustained behavioral change over decades. Longevity now requires systems-based approaches that embed healthy behaviors into everyday environments and social contexts, not temporary interventions delivered in specialized settings.
#390 ‒ AMA #84: Family health history, preventing heart disease, metabolic health, strength training efficiency, dementia risk reduction, NAD supplements, and hydration
This AMA addresses multiple dimensions of disease prevention and optimization: family history assessment as a risk stratification tool, cardiovascular disease prevention through metabolic and behavioral intervention, strength training efficiency for maintaining muscle mass and metabolic function, dementia risk reduction through modifiable factors, NAD supplementation's role in cellular energy production, and hydration's foundational importance to physiological function. The aggregate effect of these interventions addresses primary prevention across multiple chronic disease pathways relevant to longevity.
Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice
Blocking the ghrelin receptor improves muscle endurance and mitochondrial function in aging mice without affecting muscle mass or lifespan. Both genetic deletion and pharmacological inhibition restore markers of mitochondrial renewal, suggesting this pathway is a viable therapeutic target for age-related muscle decline.
Targeting an Appetite Hormone Receptor for Stronger Muscles
Suppressing the ghrelin receptor (GHSR-1a) improves muscle function and reduces sarcopenia in aging mice through enhanced mitochondrial efficiency and altered muscle fiber composition. Pharmacological inhibition of this receptor produced similar benefits in older mice, suggesting a translatable approach to sarcopenia without extending lifespan.
Longeveron publishes stem cell therapy frailty trial results
Longeveron's Phase 2b trial of allogeneic mesenchymal stem cells in older adults with frailty demonstrated safety and measurable improvements in physical performance, including gait speed and functional measures. Results published in Cell Stem Cell validate a therapeutic approach targeting age-related functional decline rather than isolated disease markers.
Targeting an Appetite Hormone Receptor for Stronger Muscles
Inhibiting the ghrelin receptor (GHSR-1a) improves muscle strength, exercise capacity, and mitochondrial function in aging mice, reducing sarcopenia markers without extending lifespan. Pharmacological inhibition via PF-5190457 replicates these effects and represents a translatable therapeutic approach.
Modifiable risk factors attenuated longevity genetic predisposition on life expectancy in the oldest old
In adults over 80, genetic predisposition for longevity loses predictive power when modifiable risk factors—smoking, physical inactivity, poor diet, excessive alcohol use—remain unaddressed. This demonstrates that behavioral interventions can substantially offset inherited longevity advantages in the oldest-old population.
Home-Based Rehab Slows Decline in Dementia-Related Disability
A home-based intervention combining occupational therapy, physical therapy, and nursing support improved physical function and reduced disability in older adults with mild cognitive impairment or early dementia. The model demonstrates that targeted, in-home support addressing both cognitive and physical decline can be sustained and accepted by this population.
Sarcopenia Therapy Targets Three Pathways Simultaneously
Rejuvenate Biomed has enrolled 198 patients in a Phase 2 trial of RJx-01, a multi-pathway therapeutic targeting COPD-induced sarcopenia through mitochondrial function, inflammation, and fibrosis. This represents the first pharmacological approach to sarcopenia, a condition that accounts for substantial disability and frailty in aging populations and currently lacks approved treatments.
Entropy of Muscle Fiber Histology Predicts Mobility in Older Adults: The Study of Muscle, Mobility, and Aging
Muscle fiber disorganization, quantified as a homeostatic dysregulation index, independently predicts mobility decline and reduced mitochondrial function in adults over 70, regardless of muscle mass. This establishes structural entropy as a measurable mechanism of skeletal muscle aging separate from loss of size alone.
ANT1 upregulation advances toward pharmacologic muscle preservation
NorthStrive's AI-driven drug discovery program identified four small-molecule candidates that increased ANT1 protein expression in human skeletal muscle cells by up to 50%, representing early-stage progress toward pharmacological muscle preservation. ANT1 modulation addresses a fundamental constraint in cellular energy metabolism relevant to aging-related muscle decline.
Muscle and Bone Loss Share Inflammatory Pathways
Sarcopenia and osteoporosis share bidirectional risk pathways mediated by inflammation, metabolic dysfunction, and genetic factors related to mitochondrial function and immune regulation. This integrated mechanism suggests that addressing muscle and bone loss requires simultaneous intervention on shared biological drivers rather than treating them as separate conditions.
Gait speed predictors shift across midlife and aging
Gait speed in middle and older adults correlates with specific physical and cognitive measures that vary across the age spectrum. Walking pace is a reliable marker of overall functional capacity and longevity risk, with certain predictors becoming more influential at different life stages.
White matter integrity peaks with moderate activity in older adults
Physical activity correlates with improved white matter integrity in the brain, but the relationship is nonlinear and varies significantly by age and brain region. In older adults and those transitioning from sedentary behavior, activity's effects on neural fiber organization are mediated partly through improvements in body composition, cardiometabolic health, and inflammatory markers.
Dizziness as Predictor of Dementia – Letter to the Editor
Dizziness and vestibular dysfunction emerge as measurable precursors to cognitive decline and dementia, suggesting that dysfunction in balance and spatial orientation systems may reflect broader neurological compromise before overt cognitive symptoms manifest. This finding repositions a common but often-overlooked symptom as a potential biomarker for early neurological risk.
Atrogi begins human trial for muscle-preserving weight loss
Atrogi has initiated human trials of ATR-258, an oral drug designed to preserve muscle mass during weight loss by mimicking exercise-induced metabolic effects. The approach addresses a critical gap in current obesity therapeutics: preventing muscle loss alongside fat loss, which is essential for maintaining strength, resilience, and functional independence in aging.
Social Balance Patterns Shape Cognitive Decline Risk in Aging
Social participation patterns in older adults show measurable associations with cognitive trajectory, with the balance between family-centered and broader community engagement emerging as a critical variable. This finding positions social structure and relational patterns as modifiable factors in cognitive resilience during aging.
Xplore Program 2026: A Remote Summer Fellowship in Longevity
The Xplore Program is a fully remote summer fellowship designed to translate longevity interest into practical biotech experience through structured education and direct project placement with partner organizations. The program addresses a critical gap: making the pathway into longevity science explicit and accessible to talented individuals outside major biotech hubs.