Genetics & Epigenetics Library

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Showing 49–72 of 88

Nature - npj AgingMar 13, 2026

DeepStrataAge: an interpretable deep-learning clock that reveals stage- and sex-divergent DNA methylation aging dynamics

DeepStrataAge, a deep-learning model trained on DNA methylation patterns, identifies distinct aging trajectories between biological sexes and developmental stages, revealing that aging acceleration is not uniform across the lifespan. This sex- and stage-specific resolution improves the precision of biological age assessment and may refine risk stratification for age-related disease prevention.

Nature - npj AgingMar 9, 2026

Epigenetic aging and cancer incidence in a German cohort of older adults

Epigenetic age acceleration—measured through DNA methylation patterns—independently predicts cancer incidence in older adults, even after accounting for chronological age and established risk factors. This biomarker offers a quantifiable proxy for biological aging that may identify individuals at elevated cancer risk before conventional screening protocols would.

Wiley Aging CellFeb 26, 2026

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment

Senolytic treatments did not reverse epigenetic signatures associated with cellular senescence, despite reducing senescent cell burden. This finding questions whether DNA methylation changes adequately capture senescence biology and whether current aging biomarkers respond as expected to geroscience interventions.

Peter Attia MDApr 6, 2026

#386 – Aging clocks—what they measure, how they work, and their clinical and real-world relevance

Aging clocks are biomarkers that quantify biological age independent of chronological time, offering a measurable framework to evaluate whether interventions actually slow aging. Their clinical utility depends on validating what they measure, understanding their mechanisms, and establishing whether changes in these markers correlate with meaningful health outcomes.

Longevity.TechnologyFeb 24, 2026

Klothea initiates longevity-focused human trial of klotho therapy

Klothea Bio has initiated a Phase 1b trial of AKL003, an mRNA therapy designed to elevate circulating alpha klotho protein levels in healthy adults. The trial represents a direct approach to testing whether increased klotho—a protein associated with organ protection and repair across multiple physiological systems—can favorably shift biomarkers linked to human lifespan and biological age.

Wiley Aging CellFeb 21, 2026

Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study

Accelerated biological aging measured by the epigenetic clock AgeAccelGrim2 was associated with increased risk of mild cognitive impairment and dementia in 6,069 cognitively unimpaired women over 9.3 years of follow-up, independent of chronological age. This establishes epigenetic markers as measurable indicators of neurodegeneration risk.

Longevity.TechnologyFeb 25, 2026

Syndex Bio’s mcPCR opens new path for early disease detection

Syndex Bio's mcPCR technology preserves DNA methylation patterns during amplification, enabling detection of disease-associated epigenetic changes from minimal samples. This advance addresses a critical gap in early disease detection and biological age assessment, with implications spanning oncology, prenatal diagnostics, and longevity research.

Longevity.TechnologyFeb 12, 2026

AI, genomics and CRISPR signal a new phase of biological innovation

AI-driven pattern recognition combined with expanded genomic sequencing and CRISPR gene editing is accelerating drug discovery and precision medicine by generating large datasets for machine learning models. This convergence enables shorter development cycles and more targeted therapeutic interventions based on individual genetic profiles.

LT WireMay 29, 2026

Klotho Cell Therapy Advances to Regulatory Testing

Klothonova has completed a GMP-grade master cell bank of cells engineered to overexpress α-Klotho protein, advancing toward regulatory approval for an encapsulated cell therapy targeting aging and age-related disease. α-Klotho restoration represents a direct intervention in fundamental aging mechanisms that affect kidney function, neurodegeneration, and vascular integrity.

Wiley Aging CellMay 20, 2026

Methionine Restriction Triggers Autophagy Through Epigenetic Control

Methionine restriction extends lifespan in yeast by reducing S-adenosylmethionine production, which prevents methylation of protein phosphatase 2A and triggers sustained autophagy. Early-stage methionine restriction appears sufficient to activate this longevity pathway, suggesting a potential therapeutic target for human healthspan extension without sustained dietary restriction.

Nature AgingMar 13, 2026

Longitudinal changes in epigenetic clocks predict survival in the InCHIANTI cohort

Longitudinal acceleration in epigenetic clocks—independent of baseline epigenetic age—predicts mortality risk in the InCHIANTI cohort. The rate of change in multiple epigenetic clocks emerges as a more predictive mortality marker than epigenetic age alone, offering refined mortality risk stratification.

Nature - npj AgingApr 4, 2026

scAgeClock: a single-cell transcriptome-based human aging clock model using gated multi-head attention neural networks

Researchers developed scAgeClock, a machine learning model that measures aging at the single-cell level by analyzing gene expression patterns. This cellular-resolution aging clock offers a novel method to detect age-related changes before systemic symptoms emerge, with potential applications in monitoring intervention efficacy and identifying individuals at accelerated aging risk.

Wiley Aging CellMar 13, 2026

Biologically Younger Individuals, as Identified by MARK‐AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age

Biological age, calculated from a 10-marker panel, correlates with HDL cholesterol, vitamin D, and immune function (CD4+ ratio) independently of chronological age. Subjects with lower biological age scores showed favorable values in these markers, suggesting they function as drivers of the aging process rather than mere correlates.

Longevity.TechnologyMar 26, 2026

GARM expands gene therapy platform with Klotho

GARM Clinic has added Klotho to its non-permanent gene therapy platform alongside Follistatin and VEGF, positioning itself as a clinical destination for early-stage longevity interventions. Klotho addresses age-related decline in the protein's natural production, targeting mitochondrial function, metabolic resilience, and systemic health markers that degrade with age.

Wiley Aging CellApr 16, 2026

An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease

Researchers developed a 14-protein aging clock from circulating extracellular matrix proteins that predicts biological age, distinguishes healthy from diseased states, and responds to rejuvenation interventions. This identifies ECM remodeling as a measurable biomarker and potential therapeutic target for age-related decline.

Longevity.TechnologyMar 5, 2026

Avaí Bio–Austrianova’s longevity protein program enters production

Avaí Bio and Austrianova have begun GMP-compliant production of a Master Cell Bank for genetically modified cells engineered to overexpress α-Klotho, a protein associated with improved cognitive resilience and organ function in aging. This transition from research to scalable manufacturing represents a critical step toward clinical cell therapy delivery for age-related disease.

LT WireMay 18, 2026

One-time gene therapy targets metabolic reset

Fractyl Health has received regulatory approval to initiate Phase 1/2 trials of RJVA-001, a single-administration gene therapy designed to enable patients' own cells to produce GLP-1 indefinitely. This represents a shift toward durable metabolic interventions that require one-time dosing rather than ongoing pharmaceutical management.

Wiley Aging CellMay 6, 2026

Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults

Higher diet quality correlates with slower epigenetic aging and reduced mortality risk in two large U.S. cohorts, with epigenetic age acceleration (GrimAgeEAA) explaining approximately 44% of the diet-mortality association in one cohort. The relationship is partially confounded by physical activity and integrated lifestyle factors, indicating that diet operates within a broader system of behavioral and biological aging pathways rather than in isolation.

Longevity.TechnologyMar 23, 2026

Garm adds Klotho to cell and gene therapy platform in Roatan

Garm LLC expanded its non-permanent plasmid gene therapy platform to include Klotho alongside existing follistatin and VEGF therapies, targeting mitochondrial function, inflammation reduction, oxidative stress management, and metabolic aging. The platform operates in Roatan, Honduras, positioning itself as a personalized longevity intervention without permanent genetic modification.

LT WireMay 15, 2026

Klotho Cell Therapy Restores Aging Protein via Encapsulation

Avaí Bio will present clinical data on an encapsulated cell therapy designed to restore circulating α-Klotho, a protein implicated in aging and metabolic regulation. The approach uses Austrianova's Cell-in-a-Box technology to sustain Klotho production, addressing a mechanism that declines with age and correlates with multiple age-related pathologies.

Wiley Aging CellApr 25, 2026

Histone Deacetylase 9 Gene Deletion Ameliorates Aging‐Related Adipose Tissue Senescence and Mitochondrial Dysfunction in Mice

HDAC9 gene deletion in mice reduces age-related fat tissue senescence and restores mitochondrial function through upregulation of thiosulfate sulfurtransferase (TST), a protein whose decline contributes to metabolic dysfunction during aging. This identifies HDAC9 as a druggable epigenetic target for preserving adipose tissue health.

Longevity.TechnologyApr 13, 2026

Microcap produces anti-aging protein from encapsulated cells

Klothonova is developing an encapsulated cell therapy designed to restore circulating α-Klotho, a protein that declines with age and influences cardiovascular, renal, and cognitive function. The approach uses genetically modified cells housed in a biocompatible capsule to sustainably produce the protein, addressing a mechanism implicated in multiple age-related conditions.

Wiley Aging CellFeb 13, 2026

Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions

Host genetic capacity to manage oxidative stress determines whether microbiota interventions extend or shorten lifespan. Individuals with genetic variants affecting redox buffering show accelerated aging when exposed to the same microbial signals that promote longevity in genetically robust hosts. This finding establishes oxidative stress management as the critical variable in microbiome-driven aging outcomes.

LifeSpan.ioApr 30, 2026

Some Researchers Choose Replacement Over Repair in Aging

Replacement-based interventions—substituting damaged cells, tissues, organs, and physiological systems with biological or synthetic alternatives—are emerging as a pragmatic complement to endogenous repair strategies in aging research. Multiple research organizations are advancing clinical applications ranging from stem cell therapies for structural injuries to bioprinted organs and genetic replacements derived from long-lived species.

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