Current anti-aging research identifies six intervention categories—metabolic modulation, inflammaging control, senotherapy, parabiosis, stem cell therapy, and epigenetic rejuvenation—each targeting distinct aging mechanisms. The most translatable approaches center on autophagy enhancement, senescent cell clearance, and mitochondrial support to reduce chronic inflammation.
Key Points
- Six classified intervention categories target distinct aging mechanisms with clinical evidence
- Metabolic modulation, inflammaging control, senotherapy form three interconnected strategic pillars
- Autophagy, senescent cell clearance, mitochondrial function are core mechanistic targets
Longevity Analysis
This framework reorders anti-aging strategy around mechanism rather than intervention type, creating a coherent foundation for clinical translation. Metabolic modulation—whether through exercise, caloric approaches, or mimetics—connects directly to energy production and regeneration capacity. Inflammaging control addresses a root driver of system-wide dysfunction across circulation, defense, and nervous system integrity. Senotherapy and stem cell approaches target cellular regeneration capacity itself. The integration of these three pillars suggests that sustainable longevity optimization requires simultaneous attention to how your body produces and manages energy, how it controls inflammatory signaling, and how it maintains cellular renewal—not sequential or isolated interventions.
Original published by Wiley Aging Cell, by Feifei Li, Yankai Wang, Gelin Wang, Jiguo Chen, Song Huang .